CHAPSO is a unique detergent with high CMC that solubilizes membrane-bound proteins in their native state. CHAPSO is capable of solubilizing opiate receptor to a state exhibiting reversible binding of opiates. Has higher solubility than CHAPS because of its more polar head group.
Simonds, W.F., et al. 1980. Proc. Natl. Acad. Sci. USA 77, 4623.
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