CHAPS A non-denaturing, zwitterionic detergent for membrane proteins

CHAPS (CAS 75621-03-3)

CHAPS | CAS 75621-03-3 is rated 5.0 out of 5 by 1.
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Synonym: 3-[(3-cholamidopropyl)dimethylammonio]-2-hydroxy-1-propanesulfonate; 3-[(3-Cholamidopropyl)dimethylammonio]-1-propanesulphonate
Application: A non-denaturing, zwitterionic detergent for membrane proteins
CAS Number: 75621-03-3
Purity: ≥99%
Molecular Weight: 614.87
Molecular Formula: C32H58N2O7S
* Refer to Certificate of Analysis for lot specific data (including water content).
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CHAPS is a non-denaturing, zwitterionic detergent derived from cholic acid. CHAPS is often used as a detergent in the solubilization and purification of membrane proteins for several advantageous reasons. CHAPS detergent is non-denaturing to membrane proteins, can solubilize proteins, disaggregate protein-protein interactions and is electrically neutral. CHAPS is also useful in ion exchange chromatography and isoelectric focusing as it is zwitterionic and does not exhibit a net charge between pH 2 to 12. The critical micelle concentration of CHAPS is 6-10mM.


References

1. Hjelmeland, L.M. 1980. Proc. Natl. Acad. Sci. U.S.A. 77: 6368-6370. PMID: 6935651
2. Ofri, D., et al. 1992. J. Neurochem. 58: 628-635. PMID: 1309566

Appearance :
Crystalline powder
Physical State :
Solid
Solubility :
Soluble in water (10 mg/ml).
Storage :
Store at 4° C
Melting Point :
157° C
Density :
1.01 g/cm3 at 20° C
pK Values :
pKa: 1.27
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
107670
Merck Index :
14: 2044
MDL Number :
MFCD00012116
SMILES :
C[C@H](CCC(=O)NCCC[N+](C)(C)CCCS(=O)(=O)[O-])[C@H]1CC[C@@H]2[C@@]1([C@H](C[C@H]3[C@H]2[C@@H](C[C@H]4[C@@]3(CC[C@H](C4)O)C)O)O)C

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Certificate of Analysis

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Rated 5 out of 5 by from Barnadas Barnadas-Rodr guez R; et al. (PubMed ID: 26244704)CHAPS is a zwitterionic surfactant derived from bile salts, most commonly used in protein purification. -SCBT Publication Review
Date published: 2015-06-05
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