Ceftazidime An antimicrobial small molecule

Ceftazidime (CAS 72558-82-8)

Ceftazidime | CAS 72558-82-8 is rated 5.0 out of 5 by 1.
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Synonym: (6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(2-carboxypropan-2-yloxyimino)acetyl]amino]-8-oxo-3-(pyridin-1-ium-1-ylmethyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
Application: An antimicrobial small molecule
CAS Number: 72558-82-8
Purity: ≥99%
Molecular Weight: 546.58
Molecular Formula: C22H22N6O7S2
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ceftazidime is an antimicrobial agent. It is used for treating febrile neutropenia in patients with cancer.


References

Hung KC, Chiu HH, Tseng YC et al. J Microbiol Immunol Infect. 36:254-9 (2003). Mustafa MM, Carlson L, Tkaczewski I et al. Pediatr Infect Dis J. 20:362-9 (2001).

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in water (slightly).
Storage :
Store at 4° C
Optical Activity :
α20/D -21.2°, c = 0.46 in methanol; α20/D -24°±2°, c = 0.5 in pH 6.0 Phosphate Buffer
IC50 :
PBP3 in penicillin-resistant Enterococcus faecium D63r membranes : IC50 = 73.18 nM; Pseudomonas aeruginosa PAO1 PBP3 : IC50 = 73.18 nM; Bocillin FL binding to PBP3 in Escherichia coli MC4100 membranes: IC50 = 128.07 nM; Bocillin FL binding to Escherichia coli MC4100 penicillin-binding protein 3: IC50 = 128.07 nM; Bocillin FL binding to PBP3 in Pseudomonas aeruginosa PAO1 membranes: IC50 = 182.96 nM
Ki Data :
Escherichia coli MC4100 βLactamase CMY-2: Ki= 20 nM; Escherichia coli MC4100 βLactamase CMY-30 : Ki= 140 nM
pK Values :
pKa: 2.43 (Predicted), pKb: 1.34 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
UU2225000
PubChem CID :
5481173
Merck Index :
14: 1946
MDL Number :
MFCD00072034
EC Number :
276-715-9
SMILES :
CC(C)(C(=O)O)ON=C(C1=CSC(=N1)N)C(=O)NC2C3N(C2=O)C(=C(CS3)C[N+]4=CC=CC=C4)C(=O)[O-]

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Certificate of Analysis

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Ceftazidime  Product Citations

See how others have used Ceftazidime. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 24819062  Borisova, M. et al. 2014. Microbial drug resistance (Larchmont, N.Y.). 20: 231-7.

PMID: # 25572750  Artini, M. et al. International journal of immunopathology and pharmacology. 27: 675-82.

Citations 1 to 2 of 2 total

What is the appearance of the compound?

Asked by: two2igm05
Thank you for your question. This chemical is supplied as a white crystalline powder. Please contact Technical Service if you have further questions concerning this product.
Answered by: Tech Service 9
Date published: 2017-01-16
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Rated 5 out of 5 by from Tamayo Tamayo, M. et al. (PubMed 22797526) reported that cell wall active antibiotics, such as Ceftazidime, reduce chromosomal DNA fragmentation by peptidoglycan hydrolysis in Staphylococcus aureus. -SCBT Publication Review
Date published: 2015-05-30
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