Cefotaxime Sodium Salt is a third generation Cephalosporin β-lactamase resistant antibiotic with efficacy in prohibition of gram-positive and gram-negative bacterial cell wall synthesis. The compound has demonstrated greater activity than other available first- and second-generation cephalosporins against Enterobacteriaceae. More active than older cephalosporins against Pseudomonas aeruginosa and Acinetobacter spp., but most strains are still considered resistant. Also active against some gram-negative bacilli that are resistant to aminoglycosides, including amikacin (sc-278692). Activity comparable with other cephalosporins against gram-positive cocci, except staphylococci and enterococci, which are resistant. In combination with penicillins or aminoglycosides may be synergistic against selected gram-negative bacilli.
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