CD 3254 is a selective RXRα agonist which is reported to not exhibit activity at RARα, RARβ or RARγ receptors. RXRα belongs to the NR2B nuclear receptor family and primarily expressed in the liver, intestines, kidneys, and epidermis.
1. Pogenberg, V., et al. 2005. J. Biol. Chem. 280: 1625-1633. PMID: 15528208
2. Nahoum, V., et al. 2007. Proc .Natl. Acad. Sci. 104: 17323-17327. PMID: 17947383
3. le Maire, A., et al. 2009. EMBO. Rep. 10: 367-373. PMID: 19270714
Soluble in ethanol (100 mM), and DMSO (100 mM).
Store at -20° C
n20D 1.59 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Rated 5 out of
le Maire et alle Maire et al. (PubMed ID 19270714) found that the RXR- agonist, CD 3254, potentiated recruitment of the fluorescein-labelled PGC-1 peptide by RXR- and PPAR- . -SCBT Publication Review
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