CAY10578 A potent inhibitor of CK2 that is also ATP competitive

CAY10578 (CAS 19231-60-8)

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Synonym: 4,5,6,7-tetraiodo-1,3-dioxo-2-isoindolineacetic acid
Application: A potent inhibitor of CK2 that is also ATP competitive
CAS Number: 19231-60-8
Molecular Weight: 708.8
Molecular Formula: C10H3I4NO4
* Refer to Certificate of Analysis for lot specific data (including water content).
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CK2 is known to negatively regulate apoptosis, and increased activity has been noted in many proliferating tissues and tumors, which lends promise as an anticancer drug target. CAY10578 is a potent inhibitor of CK2 and is ATP competitive, only minimally inhibiting the activities of other protein kinases.


References

1 Golub, A.G., Yakovenko, O.Y., Prykhod'ko, A.O., et al. Evaluation of 4,5,6,7-tetrahalogeno-1H-isoindole-1,3(2H)-diones as inhibitors of human protein kinase CK2. Biochem Biophys Acta 1784 143-149 (2008).

Physical State :
Solid
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
4462449
SMILES :
C(C(=O)O)N1C(=O)C2=C(C1=O)C(=C(C(=C2I)I)I)I

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Certificate of Analysis

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