CK2 is known to negatively regulate apoptosis, and increased activity has been noted in many proliferating tissues and tumors, which lends promise as an anticancer drug target. CAY10578 is a potent inhibitor of CK2 and is ATP competitive, only minimally inhibiting the activities of other protein kinases.
1 Golub, A.G., Yakovenko, O.Y., Prykhod'ko, A.O., et al. Evaluation of 4,5,6,7-tetrahalogeno-1H-isoindole-1,3(2H)-diones as inhibitors of human protein kinase CK2. Biochem Biophys Acta 1784 143-149 (2008).
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