CAY10500 A TNFα inhibitor that prevents binding to the TNF Receptor 1

CAY10500 (CAS 869998-49-2)

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Synonym: SPD-304; 6,7-dimethyl-3-[[methyl[2-[methyl[[1-[3-(trifluoromethyl)phenyl]-1H-indol-3-yl]methyl]amino]ethyl]amino]methyl]-4H-1-benzopyran-4-one
Application: A TNFα inhibitor that prevents binding to the TNF Receptor 1
CAS Number: 869998-49-2
Molecular Weight: 547.6
Molecular Formula: C32H32F3N3O2
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CAY10500 is a TNFα inhibitor that prevents binding to the TNF Receptor 1 (TNFR1). The compound binds to the biologically active TNFα trimer and promotes accelerated displacement of a single subunit to rapidly inactivate the cytokine. In a cell based assay, CAY10500 inhibited TNFα-mediated stimulation of IKB degradation.

Physical State :
Solid
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
5327044
SMILES :
CC1=C(C=C2C(=C1)C(=O)C(=CO2)CN(C)CCN(C)CC3=CN(C4=CC=CC=C43)C5=CC=CC(=C5)C(F)(F)F)C

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Certificate of Analysis

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