Cathepsin L inhibitorA potent and reversible inhibitor of Cathepsin L

Cathepsin L inhibitor (CAS 167498-29-5)

Cathepsin L inhibitor | CAS 167498-29-5 is rated 5.0 out of 5 by 1.
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Synonym: Cathepsin L inhibitor II; Z-Phe-Tyr-CHO
Application: A potent and reversible inhibitor of Cathepsin L
CAS Number: 167498-29-5
Purity: ≥95%
Molecular Weight: 446.49
Molecular Formula: C26H26N2O5
* Refer to Certificate of Analysis for lot specific data (including water content).
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Cathepsin L inhibitor (Z-FY-CHO) is a potent and selective inhibitor of Cathepsin L. In the pit formation assay with unfractionated rat bone cells, 1.5 nM of Z-FY-CHO markedly inhibited parathyroid hormone-stimulated osteoclastic bone resorption. In ovariectomized mice, it suppressed at 2.5-10 mg/kg/day ip for four weeks bone weight loss dose-dependently.


References

1. Woo, J T., Yamaguchi, K., Hayama, T., Kobori, T., Sigeizumi, S., Sugimoto, K., Kondo, K., Tsuji, T., Ohba, Y., Tagami, K., Sumitani, K., 1996. Suppressive effect of N-(benzyloxycarbonyl)-L-phenylalanyl-L-tyrosinal on bone resorption in vitro and in vivo. European journal of pharmacology. 300(1-2): 131-5. PMID: 8741178
2. Wille, Aline., Gerber, Annegret., Heimburg, Anke., Reisenauer, Anita., Peters, Christoph., Saftig, Paul., Reinheckel, Thomas., Welte, Tobias., Bühling, Frank., 2004. Cathepsin L is involved in cathepsin D processing and regulation of apoptosis in A549 human lung epithelial cells. Biological chemistry. 385(7): 665-70. PMID: 15318816
3. Kaasik, Allen., Rikk, Tiina., Piirsoo, Andres., Zharkovsky, Tamara., Zharkovsky, Alexander., 2005. Up-regulation of lysosomal cathepsin L and autophagy during neuronal death induced by reduced serum and potassium. The European journal of neuroscience. 22(5): 1023-31. PMID: 16176344

Usage :
For long-term storage, store lyophilized peptide dessicated at -20°C. Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Appearance :
Powder
Physical State :
Solid
Sequence :
Z-Phe-Tyr-CHO
Solubility :
Soluble in DMSO (50 mg/ml), or ethanol (50 mg/ml).
Storage :
Store at -20° C
Melting Point :
278.93° C (Predicted)
Boiling Point :
~726.5° C at 760 mmHg (Predicted)
Density :
~1.2 g/cm3 (Predicted)
Refractive Index :
n20D 1.61 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
16760360
SMILES :
C1=CC=C(C=C1)CC(C(=O)NC(CC2=CC=C(C=C2)O)C=O)NC(=O)OCC3=CC=CC=C3

Download SDS (MSDS)

Certificate of Analysis

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Cathepsin L inhibitor  Product Citations

See how others have used Cathepsin L inhibitor. Click on the entry to view the PubMed entry .

Citations 1 to 7 of 7 total

PMID: # 31223289  Mao, Z.|Sang, MM.|Chen, C.|Zhu, WT.|Gong, YS.|Pei, DS.| et al. 2019. Int. J. Biol. Sci. 15: 1310-1324.

PMID: # 28121218  Mizunoe, Y.|Sudo, Y.|Okita, N.|Hiraoka, H.|Mikami, K.|Narahara, T.|Negishi, A.|Yoshida, M.|Higashibata, R.|Watanabe, S.|Kaneko, H.|Natori, D.|Furuichi, T.|Yasukawa, H.|Kobayashi, M.|Higami, Y.| et al. 2017. Autophagy. 13: 642-653.

PMID: # 26730950  Markosyan, RM. et al. 2016. PLoS pathogens. 12: e1005373.

PMID: # 25108379  Shivanna, V. et al. 2014. Virology. 464-465: 287-95.

PMID: # 23438485  Ma, L. et al. 2013. Journal of proteome research. 12: 1924-34.

PMID: # 18255115  Gorria, M. et al. 2008. Toxicol. Appl. Pharmacol. 228: 212-224.

PMID: # 17940194  2008. Molecular pharmacology. 73: 147-56.

Citations 1 to 7 of 7 total
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Rated 5 out of 5 by from Used 10 mol used for treatment of cells Used 10 mol used for treatment of cells.
Date published: 2015-09-25
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