Cathepsin L inhibitor (Z-FY-CHO) is a potent and selective inhibitor of Cathepsin L. In the pit formation assay with unfractionated rat bone cells, 1.5 nM of Z-FY-CHO markedly inhibited parathyroid hormone-stimulated osteoclastic bone resorption. In ovariectomized mice, it suppressed at 2.5-10 mg/kg/day ip for four weeks bone weight loss dose-dependently.
1. Woo, J T., Yamaguchi, K., Hayama, T., Kobori, T., Sigeizumi, S., Sugimoto, K., Kondo, K., Tsuji, T., Ohba, Y., Tagami, K., Sumitani, K., 1996. Suppressive effect of N-(benzyloxycarbonyl)-L-phenylalanyl-L-tyrosinal on bone resorption in vitro and in vivo. European journal of pharmacology. 300(1-2): 131-5. PMID: 8741178
2. Wille, Aline., Gerber, Annegret., Heimburg, Anke., Reisenauer, Anita., Peters, Christoph., Saftig, Paul., Reinheckel, Thomas., Welte, Tobias., Bühling, Frank., 2004. Cathepsin L is involved in cathepsin D processing and regulation of apoptosis in A549 human lung epithelial cells. Biological chemistry. 385(7): 665-70. PMID: 15318816
3. Kaasik, Allen., Rikk, Tiina., Piirsoo, Andres., Zharkovsky, Tamara., Zharkovsky, Alexander., 2005. Up-regulation of lysosomal cathepsin L and autophagy during neuronal death induced by reduced serum and potassium. The European journal of neuroscience. 22(5): 1023-31. PMID: 16176344
See how others have used Cathepsin L inhibitor Inhibitor. Click on the entry to view the PubMed entry .
PMID: # 26730950 Markosyan, RM. et al. 2016. PLoS pathogens. 12: e1005373.
PMID: # 25108379 Shivanna, V. et al. 2014. Virology. 464-465: 287-95.
PMID: # 23438485 Ma, L. et al. 2013. Journal of proteome research. 12: 1924-34.
PMID: # 18255115 Gorria, M. et al. 2008. Toxicol. Appl. Pharmacol. 228: 212-224.
PMID: # 17940194 2008. Molecular pharmacology. 73: 147-56.
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