Cathepsin G Inhibitor I A cathepsin G inhibitor

Cathepsin G Inhibitor I (CAS 429676-93-7)

Cathepsin G Inhibitor I | CAS 429676-93-7 is rated 5.0 out of 5 by 1.
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Application: A cathepsin G inhibitor
CAS Number: 429676-93-7
Purity: ≥98%
Molecular Weight: 620.64
Molecular Formula: C36H33N2O6P
* Refer to Certificate of Analysis for lot specific data (including water content).
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Cathepsin G Inhibitor I is a potent, selective, reversible, competitive, non-peptide inhibitor of cathepsin G. Cathepsin G Inhibitor I weakly inhibits chymotrypsin and poorly inhibits thrombin, factor Xa, factor IXa, plasmin, trypsin, tryptase, proteinase 3, and human leukocyte elastase.


References

Greco, M.N., et al. 2002. J. Am. Chem. Soc. 124, 3810.

Physical State :
Solid
Solubility :
Soluble in DMSO (5 mg/ml), and methanol.
Storage :
Store at -20° C
Boiling Point :
912.02° C at 760 mmHg (Predicted)
Density :
1.40 g/cm3 (Predicted)
Refractive Index :
n20D 1.71 (Predicted)
IC50 :
cathepsin G: IC50 = 53 nM; leukocyte elastase: IC50 = > 100 µM (human)
Ki Data :
cathepsin G: Ki= 63 nM; chymotrypsin: Ki= 1.5 µM
pK Values :
pKa: 1.14
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
9830518
SMILES :
CN(C1CCN(CC1)C(=O)C2=CC=CC=C2)C(=O)C3=CC4=CC=CC=C4C=C3C(=O)C(C5=CC=CC6=CC=CC=C65)P(=O)(O)O

Download SDS (MSDS)

Certificate of Analysis

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Cathepsin G Inhibitor I  Product Citations

See how others have used Cathepsin G Inhibitor I. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 24532668  Brehm, A. et al. 2014. FASEB J. 28: 2318-31.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Wang Wang, J. et al. (PubMed 25037606) reported that cathepsin G deficiency due to Cathepsin G Inhibitor I reduces periaortic calcium chloride injury-induced abdominal aortic aneurysms in mice. -SCBT Publication Review
Date published: 2015-03-20
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