Caspase-8 inhibitor II A potent, cell permeable, and irreversible inhibitor of caspase-8 and granzyme B

Caspase-8 inhibitor II

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Synonym: Z-IETD-FMK; Z-Ile-Glu(O-ME)-Thr-Asp(O-Me) fluoromethyl ketone; Z-IE(OMe)TD(OMe)-FMK
Application: A potent, cell permeable, and irreversible inhibitor of caspase-8 and granzyme B
Purity: ≥98%
Molecular Weight: 654.68
Molecular Formula: C30H43FN4O11
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ordering Information

PRODUCT NAME CATALOG # UNIT PRICE QTY FAVORITES
Caspase-8 inhibitor II sc-3084 1 mg $226.00

Caspase-8 inhibitor II is a potent, cell-permeable, irreversible inhibitor of caspase-8 and granzyme B. This compound also inhibits influenza virus-induced apoptosis in HeLa cells. Caspase inhibitors play an important role in investigating biological processes and the caspase family of proteins function as key regulators of apoptotic machinery, acting to destroy specific target proteins that are critical to cell survival. Caspase-standard apoptosis assays can then be used to examine treated cells for evidence of apoptosis.
For the fluorometric determination of caspase-6 activity, the following caspase apoptosis detection kit is available from Santa Cruz: Caspase-8 Kit (sc-4267 AK).


References

1. Sweeney, E.A., Inokuchi, J. and Igarashi, Y. 1998. Inhibition of sphingolipid induced apoptosis by caspase inhibitors indicates that sphingosine acts in an earlier part of the apoptotic pathway than ceramide. FEBS Lett. 425(1): 61-65. PMID: 9541007
2. Martin, D.A., Siegel, R.M., Zheng, L. and Lenardo, M.J. 1998. Membrane oligomerization and cleavage activates the caspase-8 (FLICE/MACHalpha1) death signal. J. Biol. Chem. 273(8): 4345-4349. PMID: 9468483
3. Thornberry, N.A. and Lazebnik, Y. 1998. Caspases: enemies within. Science. 281(5381): 1312-1316. PMID: 9721091
4. Takizawa, T., Tatematsu, C., Ohashi, K. and Nakanishi, Y. 1999. Recruitment of apoptotic cysteine proteases (caspases) in influenza virus-induced cell death. Microbiol. Immunol. 43(3): 245-252. PMID: 10338194

Appearance :
Lyophilized
Physical State :
Solid
Sequence :
Z-Ile-Glu(O-Me)-Thr-Asp(O-Me)-FMK
Solubility :
Soluble in DMSO (10 mM).
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
SMILES :
C1=CC=CC=C1COC(=O)N[C@H](C(=O)NC(C(=O)N[C@H](C(=O)NC(C(CF)=O)CC(=O)OC)C(C)O)CCC(=O)OC)C(C)CC

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Certificate of Analysis

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Caspase-8 inhibitor IIProduct Citations

See how others have used Caspase-8 inhibitor II. Click on the entry to view the PubMed entry .

Citations 1 to 10 of 26 total

PMID: # 26911899
Tian, F. et al. 2016. 5-Aminolevulinic Acid-Mediated Sonodynamic Therapy Inhibits RIPK1/RIPK3-Dependent Necroptosis in THP-1-Derived Foam Cells. Scientific reports. 6: 21992.

PMID: # 27064569
2016. Anticancer Effects of 1,3-Dihydroxy-2-Methylanthraquinone and the Ethyl Acetate Fraction of Hedyotis Diffusa Willd against HepG2 Carcinoma Cells Mediated via Apoptosis. PLoS ONE. 11: e0151502.

PMID: # 26519528
Stammler, D. et al. 2015. Inhibition of Histone Deacetylases Permits Lipopolysaccharide-Mediated Secretion of Bioactive IL-1β via a Caspase-1-Independent Mechanism. J. Immunol.. 195: 5421-31.

PMID: # 25367763
Kliková, K. et al. 2015. Differential impact of bortezomib on HL-60 and K562 cells. General physiology and biophysics. 34: 33-42.

PMID: # 26367448
Chen, X. et al. 2015. Involvement of caspase-3/PTEN signaling pathway in isoflurane-induced decrease of self-renewal capacity of hippocampal neural precursor cells. Brain Res.. 1625: 275-86.

PMID: # 25596736
Zhang, J. et al. 2015. P62 regulates resveratrol-mediated Fas/Cav-1 complex formation and transition from autophagy to apoptosis. Oncotarget. 6: 789-801.

PMID: # 25202081
Kim, EY. et al. 2014. Equol induces mitochondria-mediated apoptosis of human cervical cancer cells. Anticancer Res.. 34: 4985-92.

PMID: # 24931006
Treude, F. et al. 2014. Caspase-8-mediated PAR-4 cleavage is required for TNFα-induced apoptosis. Oncotarget. 5: 2988-98.

PMID: # 24078402
2014. The novel heterocyclic trioxirane [(1,3,5-tris oxiran-2-yl)methyl)-1,3,5-triazinane-2,4,6-trione (TATT)] exhibits a better anticancer effect than platinum-based chemotherapy by induction of apoptosis and curcumin further enhances its chemosensitivity. Cell Biochem. Biophys.. 68: 597-609.

PMID: # 23994488
Marino, J. et al. 2013. Lysosomal and mitochondrial permeabilization mediates zinc(II) cationic phthalocyanine phototoxicity. Int. J. Biochem. Cell Biol.. 45: 2553-62.

Citations 1 to 10 of 26 total
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