Caspase-8 inhibitor II is a potent, cell-permeable, irreversible inhibitor of caspase-8 and granzyme B. This compound also inhibits influenza virus-induced apoptosis in HeLa cells. Caspase inhibitors play an important role in investigating biological processes and the caspase family of proteins function as key regulators of apoptotic machinery, acting to destroy specific target proteins that are critical to cell survival. Caspase-standard apoptosis assays can then be used to examine treated cells for evidence of apoptosis.
For the fluorometric determination of caspase-6 activity, the following caspase apoptosis detection kit is available from Santa Cruz: Caspase-8 Kit (sc-4267 AK).
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See how others have used Caspase-8 inhibitor II. Click on the entry to view the PubMed entry .
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