Caspase-8 inhibitor II is a potent, cell-permeable, irreversible inhibitor of caspase-8 and granzyme B. This compound also inhibits influenza virus-induced apoptosis in HeLa cells. Caspase inhibitors play an important role in investigating biological processes and the caspase family of proteins function as key regulators of apoptotic machinery, acting to destroy specific target proteins that are critical to cell survival. Caspase-standard apoptosis assays can then be used to examine treated cells for evidence of apoptosis. For the fluorometric determination of caspase-6 activity, the following caspase apoptosis detection kit is available from Santa Cruz: Caspase-8 Kit (sc-4267 AK).
1. Sweeney, E.A., Inokuchi, J. and Igarashi, Y. 1998. Inhibition of sphingolipid induced apoptosis by caspase inhibitors indicates that sphingosine acts in an earlier part of the apoptotic pathway than ceramide. FEBS Lett. 425(1): 61-65. PMID: 9541007 2. Martin, D.A., Siegel, R.M., Zheng, L. and Lenardo, M.J. 1998. Membrane oligomerization and cleavage activates the caspase-8 (FLICE/MACHalpha1) death signal. J. Biol. Chem. 273(8): 4345-4349. PMID: 9468483 3. Thornberry, N.A. and Lazebnik, Y. 1998. Caspases: enemies within. Science. 281(5381): 1312-1316. PMID: 9721091 4. Takizawa, T., Tatematsu, C., Ohashi, K. and Nakanishi, Y. 1999. Recruitment of apoptotic cysteine proteases (caspases) in influenza virus-induced cell death. Microbiol. Immunol. 43(3): 245-252. PMID: 10338194
Soluble in DMSO (10 mM).
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
To place an order using RMB or to ship to mainland China, please visit www.scbio.cn
Create a new account
Email address already exists, please enter a new valid email address.
USE YOUR SOCIAL NETWORK
Create an account quickly and easily with your preferred social network account. You won't have to remember an extra name and password.
Creating an account with us makes your shopping experience much easier and faster. You can save favorites, save cart, check order status and speed through checkout with saved addresses, payment methods and more.