Caspase-8 inhibitor II A potent, cell permeable, and irreversible inhibitor of caspase-8 and granzyme B

Caspase-8 inhibitor II (CAS 210344-98-2)

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Synonym: Z-Ile-Glu(O-ME)-Thr-Asp(O-Me) fluoromethyl ketone; Z-IETD-FMK
Application: A potent, cell permeable, and irreversible inhibitor of caspase-8 and granzyme B
CAS Number: 210344-98-2
Purity: ≥98%
Molecular Weight: 654.68
Molecular Formula: C30H43FN4O11
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ordering Information

PRODUCT NAME CATALOG # UNIT PRICE QTY FAVORITES
Caspase-8 inhibitor II sc-3084 1 mg $226.00

Caspase-8 inhibitor II is a potent, cell-permeable, irreversible inhibitor of caspase-8 and granzyme B. This compound also inhibits influenza virus-induced apoptosis in HeLa cells. Caspase inhibitors play an important role in investigating biological processes and the caspase family of proteins function as key regulators of apoptotic machinery, acting to destroy specific target proteins that are critical to cell survival. Caspase-standard apoptosis assays can then be used to examine treated cells for evidence of apoptosis.
For the fluorometric determination of caspase-6 activity, the following caspase apoptosis detection kit is available from Santa Cruz: Caspase-8 Kit (sc-4267 AK).


References

1. Sweeney, E.A., Inokuchi, J. and Igarashi, Y. 1998. Inhibition of sphingolipid induced apoptosis by caspase inhibitors indicates that sphingosine acts in an earlier part of the apoptotic pathway than ceramide. FEBS Lett. 425(1): 61-65. PMID: 9541007
2. Martin, D.A., Siegel, R.M., Zheng, L. and Lenardo, M.J. 1998. Membrane oligomerization and cleavage activates the caspase-8 (FLICE/MACHalpha1) death signal. J. Biol. Chem. 273(8): 4345-4349. PMID: 9468483
3. Thornberry, N.A. and Lazebnik, Y. 1998. Caspases: enemies within. Science. 281(5381): 1312-1316. PMID: 9721091
4. Takizawa, T., Tatematsu, C., Ohashi, K. and Nakanishi, Y. 1999. Recruitment of apoptotic cysteine proteases (caspases) in influenza virus-induced cell death. Microbiol. Immunol. 43(3): 245-252. PMID: 10338194

Appearance :
Lyophilized
Physical State :
Solid
Sequence :
Z-Ile-Glu(O-Me)-Thr-Asp(O-Me)-FMK
Solubility :
Soluble in DMSO (10 mM).
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
122173006
SMILES :
CC[C@H](C)[C@H](C(=O)N[C@H](CCC(=O)OC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@H](CC(=O)OC)C(=O)CF)NC(=O)OCC1=CC=CC=C1

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Caspase-8 inhibitor IIProduct Citations

See how others have used Caspase-8 inhibitor II. Click on the entry to view the PubMed entry .

Citations 1 to 10 of 26 total

PMID: # 26911899  Tian, F. et al. 2016. Scientific reports. 6: 21992.

PMID: # 27064569  2016. PLoS ONE. 11: e0151502.

PMID: # 26519528  Stammler, D. et al. 2015. J. Immunol. 195: 5421-31.

PMID: # 25367763  Kliková, K. et al. 2015. General physiology and biophysics. 34: 33-42.

PMID: # 26367448  Chen, X. et al. 2015. Brain Res. 1625: 275-86.

PMID: # 25596736  Zhang, J. et al. 2015. Oncotarget. 6: 789-801.

PMID: # 25202081  Kim, EY. et al. 2014. Anticancer Res. 34: 4985-92.

PMID: # 24931006  Treude, F. et al. 2014. Oncotarget. 5: 2988-98.

PMID: # 24078402  2014. Cell Biochem. Biophys. 68: 597-609.

PMID: # 23994488  Marino, J. et al. 2013. Int. J. Biochem. Cell Biol. 45: 2553-62.

Citations 1 to 10 of 26 total
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