Caspase-3 Inhibitor III A potent cell-permeable and irreversible caspase-3 inhibitor

Caspase-3 Inhibitor III (CAS 285570-60-7)

Caspase-3 Inhibitor III | CAS 285570-60-7 is rated 5.0 out of 5 by 1.
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Application: A potent cell-permeable and irreversible caspase-3 inhibitor
CAS Number: 285570-60-7
Molecular Weight: 550.94
Molecular Formula: C21H31ClN4O11
* Refer to Certificate of Analysis for lot specific data (including water content).
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Caspase-3 Inhibitor III (Ac-DEVD-CMK) is a potent cell-permeable and irreversible inhibitor of caspase-3, which is a member of the ICE-CED-3 family of cysteine proteases. Caspase inhibitors play an important role in investigating biological processes. The caspase family of proteins function as key components of the apoptotic machinery and act to destroy specific target proteins which are critical to cellular longevity. Following use of the inhibitor, standard apoptosis assays can then be used to examine treated cells for evidence of apoptosis.

For the fluorometric determination of caspase-3 activity, the following caspase apoptosis detection kit is available from Santa Cruz: Caspase-3 Kit (sc-4263 AK). Caspase-3 Inhibitor III is an inhibitor of caspase-10, caspase-6, caspase-7 and caspase-8.


References

1. Mocanu, M.M., et al. 2000. Br. J. Pharmacol. 130: 197-200. PMID: 10807653
2. Schrantz, N., et al. 1999. Cell Death Differ. 6: 445-453. PMID: 10381635
3. Thornberry, N.A. and Lazebnik, Y. 1998. Science. 281: 1312-1316. PMID: 9721091
4. Zhang, Y., et al. 2004. J. Neurosc. 24: 10616-10627. PMID: 15564577

Physical State :
Solid
Sequence :
Ac-Asp-Glu-Val-Asp-CMK
Solubility :
Soluble in DMSO (50 mg/ml).
Storage :
Store at -20° C
Boiling Point :
1048.1° C at 760 mmHg (Predicted)
Density :
1.4 g/cm3 (Predicted)
IC50 :
Caspase-3: IC50 = 13.4 µM (human)
pK Values :
pKa: 3.93 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
9959259
SMILES :
CC(C)[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)CCl)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)C

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Certificate of Analysis

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Caspase-3 Inhibitor III  Product Citations

See how others have used Caspase-3 Inhibitor III. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 25367763  Kliková, K. et al. 2015. General physiology and biophysics. 34: 33-42.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Brandhorst Brandhorst, D. et al. (PubMed 23536200) assessed whether antiapoptotic preconditioning could improve in vitro and post-transplant function of isolated human islets. They found that the caspase-3 inhibitor Ac-DEVD-CMK (Caspase-3 Inhibitor III) interfered with proinsulin conversion in preconditioned islets reducing their potency to cure diabetic mice. -SCBT Publication Review
Date published: 2015-03-29
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