Caspase-3 Inhibitor An inhibitor of caspase-3, caspase-6, caspase-7, and caspase-10

Caspase-3 Inhibitor (CAS 210344-95-9)

Caspase-3 Inhibitor | CAS 210344-95-9 is rated 5.0 out of 5 by 1.
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| See product citations (18)
Synonym: Z-DEVD-FMK
Application: An inhibitor of caspase-3, caspase-6, caspase-7, and caspase-10
CAS Number: 210344-95-9
Purity: ≥90% (solid)
Molecular Weight: 668.66
Molecular Formula: C30H41FN4O12
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ordering Information

PRODUCT NAME CATALOG # UNIT PRICE QTY FAVORITES
Caspase-3 Inhibitor sc-3075 0.5 mg $100.00

Caspase-3 inhibitor (Z-DEVD-FMK ) is a cell-permeable, potent, and irreversible inhibitor of caspase-3, caspase-6, caspase-7, caspase-8 and caspase-10. Caspase inhibitors play an important role in investigating biological processes. The caspase family of proteins function as key components of the apoptotic machinery and act to destroy specific target proteins which are critical to cellular longevity. Following use of the inhibitor, standard apoptosis assays can then be used to examine treated cells for evidence of apoptosis.
For the fluorometric determination of caspase-3 activity, the following caspase apoptosis detection kit is available from Santa Cruz: Caspase-3 Kit (sc-4263 AK).


References

1. Schlegel, J. et al. 1996. J. Biol. Chem. 271(4): 1841-1844. PMID: 8567626
2. Nicholson, D.W. 1996. Nat. Biotechnol. 14(3): 297-301. PMID: 9630889
3. Masuda, Y. et al. 1997. Biochem. Biophys. Res. Commun. 234(3): 641-645. PMID: 9175767
4. Thornberry, N.A. and Lazebnik, Y. 1998. Science. 281(5381): 1312-1316. PMID: 9721091
5. Brockstedt, E., et al., 1998. The Journal of biological chemistry. 273(43): 28057-64. PMID: 9774422
6. Henshall, D C., et al., 2000. Journal of neurochemistry. 74(3): 1215-23. PMID: 10693954
7. Kugawa, F., et al., 2000. Biological & pharmaceutical bulletin. 23(8): 930-5. PMID: 10963298
8. Nagarajah, N.S. et al. 2004. Mol. Cancer. 3(1): 38. PMID: 15613236
9. Cervantes, J. et al. 2008. Cell. Microbiol. 10(1): 41-52. PMID: 17662073

Usage :
Pretreatment with an esterase is required when using with purified native or recombinant enzyme.

We recommend a final concentration of 2-10µM for inhibiting caspase activity in cell culture. The optimal doses may vary for different cells and culture conditions.
Physical State :
Solid
Sequence :
Z-Asp(OCH3)-Glu(OCH3)-Val-Asp(OCH3)-FMK
Solubility :
Soluble in DMSO (13.37 mg/ml).
Storage :
Store at -20° C
Boiling Point :
914.21±34.3° C at 760 mmHg (Predicted)
Density :
1.3±0.1 g/cm3
Refractive Index :
n20D 1.51 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
16760394
SMILES :
CC(C)[C@@H](C(=O)N[C@@H](CC(=O)OC)C(=O)CF)NC(=O)[C@H](CCC(=O)OC)NC(=O)[C@H](CC(=O)OC)NC(=O)OCC1=CC=CC=C1

Download SDS (MSDS)

Certificate of Analysis

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Caspase-3 InhibitorProduct Citations

See how others have used Caspase-3 Inhibitor. Click on the entry to view the PubMed entry .

Citations 1 to 10 of 18 total

PMID: # 28288862
Fan, C. et al. 2017. Autophagy inhibits C2-ceramide-mediated cell death by decreasing the reactive oxygen species levels in SH-SY5Y cells. Neurosci. Lett.. 651: 198-206.

PMID: # 28499910
Aseer, KR. et al. 2017. SPARC paucity alleviates superoxide-mediated oxidative stress, apoptosis, and autophagy in diabetogenic hepatocytes. Free Radic. Biol. Med.. 108: 874-895.

PMID: # 26911899
Tian, F. et al. 2016. 5-Aminolevulinic Acid-Mediated Sonodynamic Therapy Inhibits RIPK1/RIPK3-Dependent Necroptosis in THP-1-Derived Foam Cells. Scientific reports. 6: 21992.

PMID: # 27144333
Harrison, JS. et al. 2016. The role of VDR and BIM in potentiation of cytarabine-induced cell death in human AML blasts. Oncotarget. 7: 36447-36460.

PMID: # 26519528
Stammler, D. et al. 2015. Inhibition of Histone Deacetylases Permits Lipopolysaccharide-Mediated Secretion of Bioactive IL-1β via a Caspase-1-Independent Mechanism. J. Immunol.. 195: 5421-31.

PMID: # 26517370
Yuan, F. et al. 2015. Nucleostemin Knockdown Sensitizes Hepatocellular Carcinoma Cells to Ultraviolet and Serum Starvation-Induced Apoptosis. PLoS ONE. 10: e0141678.

PMID: # 26367448
Chen, X. et al. 2015. Involvement of caspase-3/PTEN signaling pathway in isoflurane-induced decrease of self-renewal capacity of hippocampal neural precursor cells. Brain Res.. 1625: 275-86.

PMID: # 26657638
Marnef, A. et al. 2015. Human polypyrimidine tract-binding protein interacts with mitochondrial tRNAThr in the cytosol. Nucleic Acids Res..

PMID: # 24337868
Philippe, L. et al. 2014. Different routes lead to apoptosis in unfertilized sea urchin eggs. Apoptosis. 19: 436-50.

PMID: # 24992192
Sansone, C. et al. 2014. Diatom-derived polyunsaturated aldehydes activate cell death in human cancer cell lines but not normal cells. PLoS ONE. 9: e101220.

Citations 1 to 10 of 18 total

What is the solubility of this compound?

Asked by: two2igm05
Thank you for your question. The solubility of Caspase-3 Inhibitor, sc-3075, is DMSO/DMF (>=20 mM).
Answered by: Chemical Support 4
Date published: 2017-03-17
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Rated 5 out of 5 by from Nagarajah Nagarajah, NS. et al. (PubMed 15613236) used Caspase-3 Inhibitor (Z-DEVD-fmk) to create a caspase activity profile. Caspase-3 successfully inhibited activity of its target protease caspase-3, but not caspases 8 or 9. -SCBT Publication Review
Date published: 2015-04-29
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