Caspase-3 InhibitorAn inhibitor of caspase-3, caspase-6, caspase-7, and caspase-10

Caspase-3 Inhibitor (CAS 210344-95-9)

Caspase-3 Inhibitor | CAS 210344-95-9 is rated 5.0 out of 5 by 1.
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Synonym: Z-DEVD-FMK
Application: An inhibitor of caspase-3, caspase-6, caspase-7, and caspase-10
CAS Number: 210344-95-9
Purity: ≥90% (solid)
Molecular Weight: 668.66
Molecular Formula: C30H41FN4O12
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Caspase-3 inhibitor (Z-DEVD-FMK ) is a cell-permeable, potent, and irreversible inhibitor of caspase-3, caspase-6, caspase-7, caspase-8 and caspase-10. Caspase inhibitors play an important role in investigating biological processes. The caspase family of proteins function as key components of the apoptotic machinery and act to destroy specific target proteins which are critical to cellular longevity. Following use of the inhibitor, standard apoptosis assays can then be used to examine treated cells for evidence of apoptosis.
For the fluorometric determination of caspase-3 activity, the following caspase apoptosis detection kit is available from Santa Cruz: Caspase-3 Kit (sc-4263 AK).


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Usage :
Pretreatment with an esterase is required when using with purified native or recombinant enzyme.

We recommend a final concentration of 2-10µM for inhibiting caspase activity in cell culture. The optimal doses may vary for different cells and culture conditions.
Physical State :
Sequence :
Solubility :
Soluble in DMSO (13.37 mg/ml).
Storage :
Store at -20° C
Boiling Point :
~914.2° C at 760 mmHg (Predicted)
Density :
~1.3 g/cm3 (Predicted)
Refractive Index :
n20D 1.51 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :

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Caspase-3 Inhibitor  Product Citations

See how others have used Caspase-3 Inhibitor. Click on the entry to view the PubMed entry .

Citations 1 to 10 of 44 total

PMID: # 30692621  Choi, YJ. et al. 2019. Nat. Immunol. 20: 276-287.

PMID: # 30795621  Nováková, J.|Talacko, P.|Novák, P.|Vališ, K.| et al. 2019. Cells. 8:

PMID: # 31035052  Huang, WC.|Gu, PY.|Fang, LW.|Huang, YL.|Lin, CF.|Liou, CJ.| et al. 2019. Phytomedicine. 61: 152852.

PMID: # 30161272  Chen, XB.|Li, W.|Chu, AX.| et al. 2019. J. Cell. Biochem. 120: 470-480.

PMID: # 30904799  Zhao, W.|Li, H.|Hou, Y.|Jin, Y.|Zhang, L.| et al. 2019. World Neurosurg. 127: e346-e352.

PMID: # 31313541  Bishayee, K.|Habib, K.|Sadra, A.|Huh, SO.| et al. 2019. Cell. Physiol. Biochem. 53: 258-280.

PMID: # 31189945  Chambers, JS.|Brend, T.|Rabbitts, TH.| et al. 2019. Sci Rep. 9: 8553.

PMID: # 29670107  Parida, PK. et al. 2018. Cell Death Dis. 9: 448.

PMID: # 30131570  Lee, BS.|Kim, YS.|Kim, HJ.|Kim, DH.|Won, HR.|Kim, YS.|Kim, CH.| et al. 2018. Sci Rep. 8: 12520.

PMID: # 29679250  Sansone, C.|Nuzzo, G.|Galasso, C.|Casotti, R.|Fontana, A.|Romano, G.|Ianora, A.| et al. 2018. Mar. Biotechnol. 20: 343-352.

Citations 1 to 10 of 44 total

What is the solubility of this compound?

Asked by: two2igm05
Thank you for your question. The solubility of Caspase-3 Inhibitor, sc-3075, is DMSO/DMF (>=20 mM).
Answered by: Chemical Support 4
Date published: 2017-03-17
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Rated 5 out of 5 by from Nagarajah Nagarajah, NS. et al. (PubMed 15613236) used Caspase-3 Inhibitor (Z-DEVD-fmk) to create a caspase activity profile. Caspase-3 successfully inhibited activity of its target protease caspase-3, but not caspases 8 or 9. -SCBT Publication Review
Date published: 2015-04-29
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