Caspase-3 Inhibitor An inhibitor of caspase-3, caspase-6, caspase-7, and caspase-10

Caspase-3 Inhibitor (CAS 210344-95-9)

Caspase-3 Inhibitor | CAS 210344-95-9 is rated 5.0 out of 5 by 1.
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| See product citations (18)
Synonym: Z-DEVD-FMK
Application: An inhibitor of caspase-3, caspase-6, caspase-7, and caspase-10
CAS Number: 210344-95-9
Purity: ≥90% (solid)
Molecular Weight: 668.66
Molecular Formula: C30H41FN4O12
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ordering Information

PRODUCT NAME CATALOG # UNIT PRICE QTY FAVORITES
Caspase-3 Inhibitor sc-3075 0.5 mg $100.00

Caspase-3 inhibitor (Z-DEVD-FMK ) is a cell-permeable, potent, and irreversible inhibitor of caspase-3, caspase-6, caspase-7, caspase-8 and caspase-10. Caspase inhibitors play an important role in investigating biological processes. The caspase family of proteins function as key components of the apoptotic machinery and act to destroy specific target proteins which are critical to cellular longevity. Following use of the inhibitor, standard apoptosis assays can then be used to examine treated cells for evidence of apoptosis.
For the fluorometric determination of caspase-3 activity, the following caspase apoptosis detection kit is available from Santa Cruz: Caspase-3 Kit (sc-4263 AK).


References

1. Schlegel, J. et al. 1996. J. Biol. Chem. 271(4): 1841-1844. PMID: 8567626
2. Nicholson, D.W. 1996. Nat. Biotechnol. 14(3): 297-301. PMID: 9630889
3. Masuda, Y. et al. 1997. Biochem. Biophys. Res. Commun. 234(3): 641-645. PMID: 9175767
4. Thornberry, N.A. and Lazebnik, Y. 1998. Science. 281(5381): 1312-1316. PMID: 9721091
5. Brockstedt, E., et al., 1998. The Journal of biological chemistry. 273(43): 28057-64. PMID: 9774422
6. Henshall, D C., et al., 2000. Journal of neurochemistry. 74(3): 1215-23. PMID: 10693954
7. Kugawa, F., et al., 2000. Biological & pharmaceutical bulletin. 23(8): 930-5. PMID: 10963298
8. Nagarajah, N.S. et al. 2004. Mol. Cancer. 3(1): 38. PMID: 15613236
9. Cervantes, J. et al. 2008. Cell. Microbiol. 10(1): 41-52. PMID: 17662073

Usage :
Pretreatment with an esterase is required when using with purified native or recombinant enzyme.

We recommend a final concentration of 2-10µM for inhibiting caspase activity in cell culture. The optimal doses may vary for different cells and culture conditions.
Physical State :
Solid
Sequence :
Z-Asp(OCH3)-Glu(OCH3)-Val-Asp(OCH3)-FMK
Solubility :
Soluble in DMSO (13.37 mg/ml).
Storage :
Store at -20° C
Boiling Point :
~914.2° C at 760 mmHg (Predicted)
Density :
~1.3 g/cm3 (Predicted)
Refractive Index :
n20D 1.51 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
16760394
SMILES :
CC(C)[C@@H](C(=O)N[C@@H](CC(=O)OC)C(=O)CF)NC(=O)[C@H](CCC(=O)OC)NC(=O)[C@H](CC(=O)OC)NC(=O)OCC1=CC=CC=C1

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Certificate of Analysis

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Caspase-3 InhibitorProduct Citations

See how others have used Caspase-3 Inhibitor. Click on the entry to view the PubMed entry .

Citations 1 to 10 of 18 total

PMID: # 28288862  Fan, C. et al. 2017. Neurosci. Lett. 651: 198-206.

PMID: # 28499910  Aseer, KR. et al. 2017. Free Radic. Biol. Med. 108: 874-895.

PMID: # 26911899  Tian, F. et al. 2016. Scientific reports. 6: 21992.

PMID: # 27144333  Harrison, JS. et al. 2016. Oncotarget. 7: 36447-36460.

PMID: # 26519528  Stammler, D. et al. 2015. J. Immunol. 195: 5421-31.

PMID: # 26517370  Yuan, F. et al. 2015. PLoS ONE. 10: e0141678.

PMID: # 26367448  Chen, X. et al. 2015. Brain Res. 1625: 275-86.

PMID: # 26657638  Marnef, A. et al. 2015. Nucleic Acids Res.

PMID: # 24337868  Philippe, L. et al. 2014. Apoptosis. 19: 436-50.

PMID: # 24992192  Sansone, C. et al. 2014. PLoS ONE. 9: e101220.

Citations 1 to 10 of 18 total

What is the solubility of this compound?

Asked by: two2igm05
Thank you for your question. The solubility of Caspase-3 Inhibitor, sc-3075, is DMSO/DMF (>=20 mM).
Answered by: Chemical Support 4
Date published: 2017-03-17
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Rated 5 out of 5 by from Nagarajah Nagarajah, NS. et al. (PubMed 15613236) used Caspase-3 Inhibitor (Z-DEVD-fmk) to create a caspase activity profile. Caspase-3 successfully inhibited activity of its target protease caspase-3, but not caspases 8 or 9. -SCBT Publication Review
Date published: 2015-04-29
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