Caspase-1 inhibitor VI A cell-permeable, inhibitor of caspase-1, caspase-4, and caspase-5 activity

Caspase-1 inhibitor VI

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Synonym: Z-YVAD(OMe)-FMK
Application: A cell-permeable, inhibitor of caspase-1, caspase-4, and caspase-5 activity
Purity: ≥97%
Molecular Weight: 630.66
Molecular Formula: C31H39FN4O9
* Refer to Certificate of Analysis for lot specific data (including water content).
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Caspase-1 inhibitor VI (Z-YVAD-FMK) is a cell-permeable, irreversible inhibitor of caspase-1, caspase-4, and caspase-5 activity. Caspase inhibitors play an important role in investigating biological processes. The caspase family of proteins function as key components of the apoptotic machinery and act to destroy specific target proteins which are critical to cellular longevity. Caspase-1, originally designated ICE (for IL-1 converting enzyme), is a member of the group of caspases with large prodomains. Active caspase-1, a (p20/p10)2 tetramer, is necessary and sufficient for cleavage of precursor IL-1 as well as for induction of apoptosis in some cell lines. Following use of the inhibitor, standard apoptosis assays can be used to examine treated cells for evidence of apoptosis.
Additional caspase-1 inhibitors available:
Caspase-1 inhibitor (sc-3069)
Caspase-1 Inhibitor II (sc-300323)
Caspase-1 Inhibitor IV (sc-300324)
Caspase-1 Inhibitor I (sc-358878)


References

1. Auerbuch, V. et al. 2009. PLoS Pathog. 5(12): e1000686. PMID: 19997504
2. Brenner, B., et al. 1998. Cell Death Differ. 5: 29-37. PMID: 10200443
3. Garcia-Calvo, M., et al. 1998. J. Biol. Chem. 273: 32608-32613. PMID: 9829999
4. Hilbi, H., et al. 1998. J. Biol. Chem. 273: 32895-32900. PMID: 9830039
5. Thornberry, N.A, et al. 1998. Science. 281: 1312-1316. PMID: 9721091
6. Schlegel, J., et al. 1996. J. Biol. Chem. 271: 1841-1844. PMID: 8567626
7. Enari, M., et al. 1995. Nature. 375: 78-81. PMID: 7536900
8. Walker, N.P., et al. 1994. Cell. 78: 343-352. PMID: 8044845
9. Thornberry, N.A., et al. 1992. Nature. 356: 768-774. PMID: 1574116
10. Pirnia, F. et al. 2006. Anticancer Res. 26(3A): 1765-1772. PMID: 16827105

Usage :
The carboxyl groups are OMe ester forms to enhance cell permeability. If purified enzyme is used, esterase should be added for the hydrolysis of the ester groups.

Prepare a 10mM stock solution of the caspase inhibitor in high quality DMSO.

Store solution aliquots at -20°C.
Appearance :
Lyophilized powder
Physical State :
Solid
Sequence :
Z-Tyr-Val-Ala-Asp(OMe)-FMK
Solubility :
Soluble in DMSO.
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
16760349
SMILES :
CC(C)C(C(=O)NC(C)C(=O)NC(CC(=O)OC)C(=O)CF)NC(=O)C(CC1=CC=C(C=C1)O)NC(=O)OCC2=CC=CC=C2

Download SDS (MSDS)

Certificate of Analysis

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Caspase-1 inhibitor VI  Product Citations

See how others have used Caspase-1 inhibitor VI. Click on the entry to view the PubMed entry .

Citations 1 to 10 of 20 total

PMID: # 27914933  Allam, O. et al. 2017. Cytokine. 90: 144-154.

PMID: # 28871042  Chen, ML. et al. 2017. J Am Heart Assoc. 6:

PMID: # 27302486  2016. Cell. Microbiol.

PMID: # 27289225  2016. Mol. Neurobiol.

PMID: # 26809137  2016. Toxicol. Lett. 246: 7-16.

PMID: # 26986854  2016. Biomaterials. 90: 27-39.

PMID: # 26327597  Estruch, M. et al. 2015. Biochimica et biophysica acta. 1851: 1442-9.

PMID: # 25946018  2015. PLoS Pathog. 11: e1004853.

PMID: # 25680906  2015. J. Mol. Cell. Cardiol. 81: 96-106.

PMID: # 26598133  2015. Sci Rep. 5: 17205.

Citations 1 to 10 of 20 total

Can Caspase-1 inhibitor VI be used in animal tissues?

Asked by: ChemSynth123
Thank you for your question. Caspase-1 inhibitor VI, sc-3071, can be used in animal tissue. Please refer to the following reference: 10. Pirnia, F. et al. 2006. Anticancer Res. 26(3A): 1765-1772. PMID: 16827105. SFJ
Answered by: TechService7
Date published: 2018-03-06
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