Carvedilol An α1- and β-adrenergic receptor antagonist

Carvedilol (CAS 72956-09-3)

Carvedilol | CAS 72956-09-3 is rated 5.0 out of 5 by 1.
  • y_2018, m_12, d_14, h_5
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.9
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_200157, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 37ms
  • REVIEWS, PRODUCT
Synonym: 1-(9H-Carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-2-propanol
Application: An α1- and β-adrenergic receptor antagonist
CAS Number: 72956-09-3
Purity: ≥98%
Molecular Weight: 406.5
Molecular Formula: C24H26N2O4
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Carvedilol is a AR (α1 and β-adrenergic receptor) antagonist with antioxidant properties. Studies show that the receptors α1D-AR and α1B-AR have a greater affinity for Carvedilol in comparison to the receptor β1-AR subtype. Carvedilol has been observed to block the oscillatory intracellular calcium changes induced by α1D-AR and α1B-AR, and shown to have a higher oxidative effect than Atenolol (sc-204895). The S(-) enantiomer of Carvedilol acts as a β-blocker, and the R(+) and S (-) enantionmers both block the α1. Carvedilol is an inhibitor of α1B-AR, β1-AR, β2-AR and α1D-AR.


References

1. Koshimizu, T.A., et al. 2004. Cardiovasc. Res. 63: 662-672. PMID: 15306222
2. Shannon, R. and Chaudhry, M. 2006. Am. Heart J. 152: 842-850. PMID: 17070143
3. Jonsson, G., et al. 2007. J. Cardiovasc. Pharmacol. 49: 27-32. PMID: 17261960
4. Othman, A.A., et al. 2007. AAPS J. 9: E208-E218. PMID: 17614362
5. Stafylas, P.C., et al. 2008. Vasc Health Risk Manag. 4: 23-30. PMID: 18629377

Physical State :
Solid
Solubility :
Soluble in DMSO (>25 mg/ml), ethanol (10 mg/ml), methanol (33.8 mg/ml), phosphate buffer (pH 4) (0.43 mg/ml) at 37° C, water (partly miscible), chloroform, methylene chloride, and ethyl ether (slightly soluble). Insoluble in isopropanol.
Storage :
Store at room temperature
Melting Point :
115-119° C
Boiling Point :
655.22° C at 760 mmHg (Predicted)
Density :
1.25 g/cm3 (Predicted)
Refractive Index :
n20D 1.66 (Predicted)
IC50 :
Sodium channel protein type VIII alpha subunit: IC50 = 306 nM (rat); HERG: IC50 = 350 nM (human)
Ki Data :
Beta-1 adrenergic receptor: Ki= 0.81 nM (rat); β2-adrenoceptor: Ki= 0.96 nM; α1-adrenoceptor: Ki= 2.2 nM
pK Values :
pKa: 13.9 (Predicted), pKb: 5.97
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
UA8670000
Transport :
UN 3077, Class 9, Packing group III
PubChem CID :
2585
Merck Index :
14: 1873
MDL Number :
MFCD00864692
SMILES :
COC1=CC=CC=C1OCCNCC(COC2=CC=CC3=C2C4=CC=CC=C4N3)O

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 160ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Rated 5 out of 5 by from Ding Ding, Q. et al. (PubMed 26327764) reported that the 1- and -adrenergic receptor antagonist Carvedilol may attenuate liver cirrhosis by inhibiting angiogenesis through the VEGF-Src-ERK signaling pathway. -SCBT Publication Review
Date published: 2015-07-16
  • y_2018, m_12, d_14, h_5
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.9
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_200157, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 221ms
  • REVIEWS, PRODUCT
--%>

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2018 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.