Carnosol A phytopolyphenol found in Rosemary that functions as an antioxidant, antimicrobial, & anticarcinogen

Carnosol (CAS 5957-80-2)

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Synonym: 1,3,4,9,10,10aS-hexahydro-5,6-dihydroxy-1,1-dimethyl-7-isopropyl-2H-9S,4aR-(epoxymethano)phenanthren-12-one
Application: A phytopolyphenol found in Rosemary that functions as an antioxidant, antimicrobial, & anticarcinogen
CAS Number: 5957-80-2
Purity: >96%
Molecular Weight: 330.42
Molecular Formula: C20H26O4
* Refer to Certificate of Analysis for lot specific data (including water content).
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Carnosol is a naturally occurring phytopolyphenol found in rosemary that functions as an antioxidant, antimicrobial, and anticarcinogen. Carnosol has been shown to inhibit inductions of COX-2 by blocking PKC signaling. Carnosol is an inhibitor of AR and ER α.


References

Subbaramaiah K, Cole PA, Dannenberg AJ. Cancer Res. 62:2522-30 (2002). Lo AH, Liang YC, Lin-Shiau SY et al. Carcinogenesis. 23:983-91 (2002).

Physical State :
Solid
Solubility :
Soluble in DMSO (250 mg/ml), ethanol (8 mg/ml), methanol (5 mg/ml), DMF (35 mg/ml), and PBS(pH7.2) (<0.03 mg/ml).
Storage :
Store at -20° C
Melting Point :
210-220° C
Boiling Point :
~524.8° C at 760 mmHg (Predicted)
Density :
~1.3 g/cm3 (Predicted)
Refractive Index :
n20D 1.61 (Predicted)
Ki Data :
Pancreatic Lipase: Ki= 13 µM (human); MCF7: Ki= 40.9 µM (human); HeLa: Ki= 43.9 µM (human); A549: Ki= 47 µM (human); Vero: Ki= 51.5 µM (Chlorocebus aethiops)
pK Values :
pKa: 8.91 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
442009
Merck Index :
14: 10298
MDL Number :
MFCD02752467
SMILES :
CC(C)C1=C(C(=C2C(=C1)[C@@H]3C[C@@H]4[C@@]2(CCCC4(C)C)C(=O)O3)O)O

Download SDS (MSDS)

Certificate of Analysis

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