Carbachol An anti-apoptosis agent and TNF-α inhibitor

Carbachol (CAS 51-83-2)

Carbachol | CAS 51-83-2 is rated 5.0 out of 5 by 2.
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Synonym: Carbamoylcholine chloride; (2-Carbamoyloxyethyl)trimethylammonium chloride
Application: An anti-apoptosis agent and TNF-α inhibitor
CAS Number: 51-83-2
Purity: ≥99%
Molecular Weight: 182.65
Molecular Formula: C6H15N2O2•Cl
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Carbachol is shown to be a non-selective muscarinic cholinergic receptor (mAChR M) and AChR agonist that causes inhibition of apoptosis in cultured rat cerebellar granule neurons. The anti-apoptotic effects of this compound can be completely blocked by 4-diphenylacetoxyl-N methylpiperidine methiodide. Additionally, this agent has been demonstrated to prevent an increase in endothelial cell permeability induced by TNF-α and also cause a decrease in phosphor-ERK1/2 and phosphor-JNK 1.


References

1. Yan, G.M., et al. 1995. Mol. Pharmacol. 47: 248-257. PMID: 7870032
2. Yamada, T., et al. 1997. Jpn. J. Pharmacol. 73: 311-316. PMID: 9165367
3. Lin, A.L., et al. 2008. Am. J. Physiol., Cell Physiol. 294: C1454-C1464. PMID: 18385290
4. Xu, D.Y., et al. 2008. Life Sci. 82: 1083-1091. PMID: 18440028
5. Li, Y.Z., et al. 2010. Acta Pharmacol Sin. [Epub ahead of print]. PMID: 20871620

Physical State :
Solid
Solubility :
Soluble in water (1 g/ml), ethanol (20 mg/ml), methanol (100 mg/ml), and DMSO (50 mM). Insoluble in acetone, chloroform, and ether.
Storage :
Desiccate at room temperature
Melting Point :
210° C (dec.)
IC50 :
Muscarinic acetylcholine receptor: IC50 = 6.7 nM (Rattus norvegicus); Muscarinic acetylcholine receptor M2: IC50 = 34 nM (Rattus norvegicus); Muscarinic acetylcholine receptor M3: IC50 = 5.5 µM (Rattus norvegicus); Muscarinic acetylcholine receptor M2: IC50 = 3.8 nM (human); Muscarinic acetylcholine receptor M3: IC50 = 0.88 µM (human); Muscarinic acetylcholine receptor M2: EC5050 = 0.7 µM (human); Muscarinic acetylcholine receptor M1: EC5050 = 3.81 µM (human); Aorta: EC5050 = 0.51 µM (Rattus norvegicus)
Ki Data :
Muscarinic acetylcholine receptor: Ki= 9 nM (Rattus norvegicus); Muscarinic acetylcholine receptor M1: Ki= 19.9 nM (Mus musculus); Muscarinic acetylcholine receptor M1: Ki= 31 nM (Rattus norvegicus); Muscarinic acetylcholine receptor M4: Ki= 24 nM (human)
pK Values :
pKa: 12.54
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
GA0875000
Transport :
UN 2811, Class 6.1, Packing group II
PubChem CID :
5831
Merck Index :
14: 1779
MDL Number :
MFCD00012011
EC Number :
200-127-3
Beilstein Registry :
3917459
SMILES :
C[N+](C)(C)CCOC(=O)N.[Cl-]

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Carbachol  Product Citations

See how others have used Carbachol. Click on the entry to view the PubMed entry .

Citations 1 to 4 of 4 total

PMID: # 27606143  Çakmak, E. et al. 2016. Balkan Med J. 33: 453-7.

PMID: # 25269881  Lau, CG. et al. 2014. Mol. Reprod. Dev. 81: 994-1008.

PMID: # 9668091  Murga, C. et al. 1998. J. Biol. Chem. 273: 19080-19085.

PMID: # 9770463  Ma , Y.C. et al. 1998. Proc. Natl. Acad. Sci. USA. 95: 12197-12201.

Citations 1 to 4 of 4 total
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Rated 5 out of 5 by from Received promptly and worked fine Received promptly and worked fine.
Date published: 2015-09-22
Rated 5 out of 5 by from Ma Ma, et. al. (PubMed ID 9770463) treated Gq (Q209L) transfected DT40 lymphoma cells with 100 M carbachol for 5 minutes prior to harvesting cells in order to observe the interaction of endogenous Btk and Gq . -SCBT Publication Review
Date published: 2015-05-22
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