Carbachol is shown to be a non-selective muscarinic cholinergic receptor (mAChR M) and AChR agonist that causes inhibition of apoptosis in cultured rat cerebellar granule neurons. The anti-apoptotic effects of this compound can be completely blocked by 4-diphenylacetoxyl-N methylpiperidine methiodide. Additionally, this agent has been demonstrated to prevent an increase in endothelial cell permeability induced by TNF-α and also cause a decrease in phosphor-ERK1/2 and phosphor-JNK 1.
1. Yan, G.M., et al. 1995. Mol. Pharmacol. 47: 248-257. PMID: 7870032 2. Yamada, T., et al. 1997. Jpn. J. Pharmacol. 73: 311-316. PMID: 9165367 3. Lin, A.L., et al. 2008. Am. J. Physiol., Cell Physiol. 294: C1454-C1464. PMID: 18385290 4. Xu, D.Y., et al. 2008. Life Sci. 82: 1083-1091. PMID: 18440028 5. Li, Y.Z., et al. 2010. Acta Pharmacol Sin. [Epub ahead of print]. PMID: 20871620
Soluble in water (1 g/ml), ethanol (20 mg/ml), methanol (100 mg/ml), and DMSO (50 mM). Insoluble in acetone, chloroform, and ether.
bvseo-msg: The resource to the URL or file is currently unavailable.;
Rated 5 out of
Received promptly and worked fineReceived promptly and worked fine.
Date published: 2015-09-22
Rated 5 out of
MaMa, et. al. (PubMed ID 9770463) treated Gq (Q209L) transfected DT40 lymphoma cells with 100 M carbachol for 5 minutes prior to harvesting cells in order to observe the interaction of endogenous Btk and Gq . -SCBT Publication Review
To place an order using RMB or to ship to mainland China, please visit www.scbio.cn
Create a new account
Email address already exists, please enter a new valid email address.
USE YOUR SOCIAL NETWORK
Create an account quickly and easily with your preferred social network account. You won't have to remember an extra name and password.
Creating an account with us makes your shopping experience much easier and faster. You can save favorites, save cart, check order status and speed through checkout with saved addresses, payment methods and more.