Carbachol is shown to be a non-selective muscarinic cholinergic receptor (mAChR M) and AChR agonist that causes inhibition of apoptosis in cultured rat cerebellar granule neurons. The anti-apoptotic effects of this compound can be completely blocked by 4-diphenylacetoxyl-N methylpiperidine methiodide. Additionally, this agent has been demonstrated to prevent an increase in endothelial cell permeability induced by TNF-α and also cause a decrease in phosphor-ERK1/2 and phosphor-JNK 1.
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Soluble in water (1 g/ml), ethanol (20 mg/ml), methanol (100 mg/ml), and DMSO (50 mM). Insoluble in acetone, chloroform, and ether.
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Date published: 2015-09-22
Rated 5 out of
MaMa, et. al. (PubMed ID 9770463) treated Gq (Q209L) transfected DT40 lymphoma cells with 100 M carbachol for 5 minutes prior to harvesting cells in order to observe the interaction of endogenous Btk and Gq . -SCBT Publication Review
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