CAPS Used to formulate CAPS buffer, a zwitterionic buffer useful in the range of pH 7.9-11.1

CAPS (CAS 1135-40-6)

CAPS | CAS 1135-40-6 is rated 5.0 out of 5 by 1.
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Synonym: 3-(Cyclohexylamino)-1-propanesulfonic acid
Application: Used to formulate CAPS buffer, a zwitterionic buffer useful in the range of pH 7.9-11.1
CAS Number: 1135-40-6
Purity: ≥98%
Molecular Weight: 221.31
Molecular Formula: C9H19NO3S
* Refer to Certificate of Analysis for lot specific data (including water content).
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CAPS (N-cyclohexyl-3-aminopropanesulfonic acid) buffer salt is used to formulate CAPS buffer, a zwitterionic buffer that is useful in the range of pH 7.9-11.1. CAPS buffer is widely used in Western and immunoblotting experiments as well as protein sequencing and identification. Used in the electrotransfer of proteins to PVDF (sc-3723) or nitrocellulose membranes (sc-3718, sc-3724). The high pH of this buffer makes it useful for the transfer of proteins with a pI > 8.5. CAPS is not one of the original Good's buffers, although it has a similar structure to the other propanesulfonic acids and was selected as a highly water soluble buffering reagent with an optimum buffering pH of 10.4 and minimal reactivity with enzymes or proteins, minimal salt effects.
Also available:
CAPSO (sc-239475)
CAPSO sodium salt(sc-285280)


References

1. Oberley, T.D., et al. 1983. Exp. Cell Res. 145: 265-276. PMID: 6861897
2. Kaushal, V., et al. 1986. Anal. Biochem. 157: 291-294. PMID: 3777432
3. Zaitseva, J., et al. 2004. Acta Crystallogr. D Biol. Crystallogr. 60: 1076-1084. PMID: 15159567
4. Striegler, S., et al. 2010. Inorg Chem. 49: 2639-2648. PMID: 20166683

Appearance :
Crystalline powder
Physical State :
Solid
Solubility :
Soluble in water (100 g/l) at 20° C, and methanol (1%).
Storage :
Store at room temperature
Melting Point :
>300° C (lit.)
Density :
~1.20 g/cm3 (Predicted)
Refractive Index :
n20D 1.52 (Predicted)
pK Values :
pKa: 10.40 (20 deg C), pKb: 2.88
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
TZ6395000
PubChem CID :
70815
Merck Index :
14: 1767
MDL Number :
MFCD00003837
EC Number :
214-492-1
Beilstein Registry :
2835588
SMILES :
C1CCC(CC1)NCCCS(=O)(=O)O

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Certificate of Analysis

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Rated 5 out of 5 by from Various publications cite the use of CAPS (N Various publications cite the use of CAPS (N-cyclohexyl-3-aminopropanesulfonic acid) buffer salt to formulate CAPS buffer, a zwitterionic buffer that is useful in the range of pH 7.9-11.1. CAPS buffer is widely used in Western and immunoblotting experiments as well as protein sequencing and identification. -SCBT Publication Review
Date published: 2015-06-18
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