CaM Kinase II Inhibitor Blocks activation of CaM Kinase II

CaM Kinase II Inhibitor

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Synonym: CaMKII (290-309), Ca2+/calmodulin-dependent protein kinase II (290-309); LKKFNARRKLKGAILTTMLA
Application: Blocks activation of CaM Kinase II
Purity: ≥97% pure by HPLC
Molecular Weight: 2273.8
Molecular Formula: C103H185N31O24S1
* Refer to Certificate of Analysis for lot specific data (including water content).
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CaM Kinase ll Inhibitor blocks activation of CaM Kinase II. This peptide is a potent calmodulin antagonist and an inhibitor for calcium/calmodulin-dependent protein kinase II (CaMKII), which belongs to the CAMK Ser/Thr protein kinase family. The sequence is derived from the residues 290-309 within the calmodulin-binding domain of human CaMKII alpha. CaMKII is a prominent kinase in the central nervous system that functions in long-term potentiation and neurotransmitter release. This peptide inhibits CaMKII activation by blocking calmodulin binding to CaMKII.

Physical State :
Solid
Sequence :
Leu-Lys-Lys-Phe-Asn-Ala-Arg-Arg-Lys-Leu-Lys-Gly-Ala-Ile-Leu-Thr-Thr-Met-Leu-Ala
Solubility :
Soluble in water (up to 2 mg/ml).
Storage :
Desiccate at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Download SDS (MSDS)

Certificate of Analysis

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