CaM Kinase II Inhibitor

Synonym: CaMKII (290-309), Ca2+/calmodulin-dependent protein kinase II (290-309); LKKFNARRKLKGAILTTMLA

Application: Blocks activation of CaM Kinase II

Purity: ≥97% pure by HPLC

Molecular Weight: 2273.8

Molecular Formula: C₁₀₃H₁₈₅N₃₁O₂₄S₁

* Refer to Certificate of Analysis for lot specific data (including water content).

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SDS & Certificate of Analysis

CaM Kinase ll Inhibitor blocks activation of CaM Kinase II. This peptide is a potent calmodulin antagonist and an inhibitor for calcium/calmodulin-dependent protein kinase II (CaMKII), which belongs to the CAMK Ser/Thr protein kinase family. The sequence is derived from the residues 290-309 within the calmodulin-binding domain of human CaMKII alpha. CaMKII is a prominent kinase in the central nervous system that functions in long-term potentiation and neurotransmitter release. This peptide inhibits CaMKII activation by blocking calmodulin binding to CaMKII.

Physical State :

Solid

Sequence :

Leu-Lys-Lys-Phe-Asn-Ala-Arg-Arg-Lys-Leu-Lys-Gly-Ala-Ile-Leu-Thr-Thr-Met-Leu-Ala

Solubility :

Soluble in water (up to 2 mg/ml).

Storage :

Desiccate at -20° C

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

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Certificate of Analysis

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CaM Kinase II Inhibitor

QUICK LINKS

Download SDS (MSDS)

Certificate of Analysis

CaM Kinase II Inhibitor

QUICK LINKS

Download SDS (MSDS)

Certificate of Analysis

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