Calyculin A

Calyculin A (CAS 101932-71-2)

Calyculin A | CAS 101932-71-2 is rated 5.0 out of 5 by 2.
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| See product citations (22)
Application: A PP1 and PP2A-C inhibitor and tumor inducer
CAS Number: 101932-71-2
Purity: ≥98%
Molecular Weight: 1009.17
Molecular Formula: C50H81N4O15P
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Ordering Information

Calyculin A sc-24000 10 µg $55.00
Calyculin A sc-24000A 100 µg $331.00
Calyculin A sc-24000B 500 µg $1,365.00
Calyculin A sc-24000C 1 mg $2,500.00

Calyculin A, a marine toxin isolated from Disodermia calyx, is a structurally distinct inhibitor of protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A-C). It has been shown that calyculin A displays inhibitory properties towards the endogenous phosphatase of smooth muscle myosin B and induces contraction in the muscle fibers. Contraction induced by calyculin A was accompanied by an increase in the cytosolic free Ca2+ concentration. Additionally it has been reported that this compound can bind to protein phosphatases in mouse skin, which serve as okadaic acid receptors. Consequentially, calyculin A induces ornithine decarboxylase in the mouse skin and is believed to promote tumor growth.


1. Ishihara, H., et al. 1989. Biochem. Biophys. Res. Commun. 159: 871-877. PMID: 2539153
2. Ishihara, H., et al. 1989. J. Pharmacol. Exp. Ther. 250: 388-396. PMID: 2545866
3. Suganuma, M., et al. 1990. Cancer Res. 50: 3521-3525. PMID: 2160320
4. Bruno, M.K., et al. 1998. Toxicol. Appl. Pharmacol. 153: 119-132. PMID: 9875306

Physical State :
Solubility :
Soluble in DMSO (50 mM), ethanol (1 mg/ml), methanol, acetone, acetonitrile, chloroform, methylene chloride, and benzene. Insoluble in water.
Storage :
Store at -20° C
Melting Point :
247° C
Density :
1.26 g/cm3
Refractive Index :
n20D 1.57
IC50 :
PP1: IC50 = ~1 nM; PP2A: IC50 = ~1 nM; Protein-tyrosine phosphatase 1B: IC50 = 0.5 nM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
Transport :
UN 3462, Class 6.1, Packing group III
PubChem CID :
Merck Index :
14: 1724
MDL Number :
Beilstein Registry :

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Certificate of Analysis

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Calyculin AProduct Citations

See how others have used Calyculin A. Click on the entry to view the PubMed entry .

Citations 1 to 10 of 22 total

PMID: # 28515316
Tomimatsu, N. et al. 2017. DNA-damage-induced degradation of EXO1 exonuclease limits DNA end resection to ensure accurate DNA repair. J. Biol. Chem.. 292: 10779-10790.

PMID: # 26345496
Plescher, M. et al. 2015. TSC2 mediates hyperosmotic stress-induced inactivation of mTORC1. Sci Rep. 5: 13828.

PMID: # 25517148
Shirokova, N. et al. 2014. Oxidative stress and ca(2+) release events in mouse cardiomyocytes. Biophys. J.. 107: 2815-27.

PMID: # 24784579
Haage, A. et al. 2014. Cellular contractility and extracellular matrix stiffness regulate matrix metalloproteinase activity in pancreatic cancer cells. FASEB J.. 28: 3589-99.

PMID: # 25038041
Lang, RA. et al. 2014. p120-catenin-dependent junctional recruitment of Shroom3 is required for apical constriction during lens pit morphogenesis. Development. 141: 3177-87.

PMID: # 24878529
Haage, A. et al. 2014. Matrix metalloproteinase-14 is a mechanically regulated activator of secreted MMPs and invasion. Biochem. Biophys. Res. Commun.. 450: 213-8.

PMID: # 24600006
Jamin, A. et al. 2014. Cell- and virus-mediated regulation of the barrier-to-autointegration factor's phosphorylation state controls its DNA binding, dimerization, subcellular localization, and antipoxviral activity. J. Virol.. 88: 5342-55.

PMID: # 23195829
Lutz, S. et al. 2013. RhoGEF17, a Rho-specific guanine nucleotide exchange factor activated by phosphorylation via cyclic GMP-dependent kinase Iα. Cell. Signal.. 25: 630-8.

PMID: # 23208958
Morad SA, et al. 2012. A novel semisynthetic inhibitor of the FRB domain of mammalian target of rapamycin blocks proliferation and triggers apoptosis in chemoresistant prostate cancer cells. Mol Pharmacol.. 83: 531-541.

PMID: # 22366233
Alturkmani, HJ. et al. 2012. Selenate enhances STAT3 transcriptional activity in endothelial cells: differential actions of selenate and selenite on LIF cytokine signaling and cell viability. Journal of inorganic biochemistry. 109: 9-15.

Citations 1 to 10 of 22 total

Due to the small quantity, what is the best way to recover the sample from the vial?

Asked by: SCchem16
Thank you for your question. This chemical, Calyculin A (CAS 101932-71-2): sc-24000, is soluble in DMSO and ethanol. Try dissolving it in either of these solvents to get the sample out.
Answered by: Technical Support
Date published: 2016-12-13
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Rated 5 out of 5 by from Product sc Product sc-24000 (50nM, 20 minutes incubation) was used successfully to analyze prematurely condensed chromosomes (PCC). Mouse MEF cell lines were utilized (PubMed ID 20813759). -SCBT Publication Review
Date published: 2015-03-04
Rated 5 out of 5 by from To determine if Ser/Thr protein phosphatases To determine if Ser/Thr protein phosphatases such as PP2A serve an important role in the mTOR signaling pathway in mammalian cells, Calyculin A (SCBT product # sc-24000) was used to pre-treat PC-3 cells, followed by C-K BA treatment.
Date published: 2015-03-04
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