Calpeptin is a cell permeable calpain inhibitor. Research shows that Calpeptin is an effective inhibitor of calpain 2 and can fully block cleavage of PLC-β 3 enzymes. Additionally, Calpeptin has demonstrated the ability to inhibit the activities of cathepsin L and calpain-1. In muscle cell studies Calpeptin blocked the expression of aspartyl protease cathepsin D, amyloid precursor protein, and calparin. Pulmonary fibrosis research in mice have reported that Calpeptin can decrease expression of TGF-β1, IL-6, collage type Iα1, and angiopoietin-1 mRNA. Calpeptin is an inhibitor of Calpain 1, cathepsin K, cathepsin L and PTP. Calpeptin is an activator of Rock.
1. Ebisui, C., et al. 1994. Biochem. Mol. Biol. Int. 32: 515-521. PMID: 8032318 2. Figueiredo-Pereira, M.E., et al. 1994. J. Neurochem. 62: 1989-1994. PMID: 8158145 3. Banno, Y. et al. 1995. J. Biol. Chem. 270: 4318-4324. PMID: 7876193 4. Bioorg. Med. Chem. Lett. (1997) 7:539-544 5. Leung, D. et al. 2000. J. Med. Chem. 43(3): 305-341. PMID: 10669559 6. Catalano, J.G. et al. 2004. Bioorg. Med. Chem. Lett. 14(1): 275-278. PMID: 14684342 7. Catalano, J.G. et al. 2004. Bioorg. Med. Chem. Lett. 14(3): 719-722. PMID: 14741275 8. Tabata, C., et al. 2010. Clin Exp Immunol. PMID: 20846163 9. Nozaki, K., et al. 2010. Exp. Neurol. 225: 430-435. PMID: 20673830 10. Formisano, L. et al. 2011. J. Pharmacol. Exp. Ther. 338(3): 997-1003. PMID: 21693630
Stock solutions are stable for up to 2 months when stored at - 20°C.
Soluble in DMSO (5 mg/ml), DMF (5 mg/ml), and ethanol (25 mg/ml).
I am trying to assess concentration of calpeptin that should be used in our in vitro studies: many papers mention a concentration of 1U/ml, however, there is no information re enzyme unit coming with your product. Could you please comment/advise? Many tha
Asked by: nickname123
Thank you for your question. The enzyme activity of sc-202516 has not been tested.
Answered by: Technical Support
Date published: 2017-12-07
Is this product stable at 4˚C?
Asked by: hawkeye11
This chemical, Calpeptin (CAS 117591-20-5), is stable for about a month at 4˚C.
Rated 5 out of
FormisanoFormisano, L. et al. (PubMed 21693630) found that Calpeptin, a cell permeable calpain inhibitor, prevented cell death from exposure to Aroclor 1254. -SCBT Publication Review
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