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Caffeine is a CNS stimulant that blocks Adenosine A1-R and Adenosine A2A-R. Caffeine is also a cAMP phosphodiesterase inhibitor. Caffeine interferes with the uptake and storage of Ca2+ by the sarcoplasmic reticulum in skeletal muscle and prevents apoptosis and cell cycle effects induced by various chemicals. Caffeine inhibits cellular DNA repair mechanism and displays anti-inflammatory properties. Caffeine is found in tea leaves, coffee beans, cocoa beans, matε leaves, guarana paste and kola nuts.
See how others have used Caffeine. Click on the entry to view the PubMed entry .
PMID: # 26852703
Hwang, JH. et al. 2016. Caffeine prevents LPS-induced inflammatory responses in RAW264.7 cells and zebrafish. Chem. Biol. Interact.. 248: 1-7.
PMID: # 19401462
Zhou, J. et al. 2009. Loss of cardiolipin leads to longevity defects that are alleviated by alterations in stress response signaling. J. Biol. Chem.. 284: 18106-18114.
PMID: # 19136558
Varmeh, S. et al. 2009. Inappropriate activation of cyclin-dependent kinases by the phosphatase Cdc25b results in premature mitotic entry and triggers a p53-dependent checkpoint. J. Biol. Chem.. 284: 9475-9488.
PMID: # 19778904
Gallego-Sandín, S. et al. 2009. The endoplasmic reticulum of dorsal root ganglion neurons contains functional TRPV1 channels. J. Biol. Chem.. 284: 32591-32601.
PMID: # 19202191
Huertas, P. et al. 2009. Human CtIP mediates cell cycle control of DNA end resection and double strand break repair. J. Biol. Chem.. 284: 9558-9565.
PMID: # 19843516
Oddoux, S. et al. 2009. Triadin deletion induces impaired skeletal muscle function. J. Biol. Chem.. 284: 34918-34929.
PMID: # 19706608
Jin, Y. et al. 2009. Use of a riboswitch-controlled conditional hypomorphic mutation to uncover a role for the essential csrA gene in bacterial autoaggregation. J. Biol. Chem.. 284: 28738-28745.
PMID: # 19237545
Sharifmoghadam, MR. et al. 2009. The fission yeast SEL1 domain protein Cfh3p: a novel regulator of the glucan synthase Bgs1p whose function is more relevant under stress conditions. J. Biol. Chem.. 284: 11070-11079.
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