Caffeic Acid is an endogenous phenolic phytochemical compound that exists in plants and many foods. A major metabolite product upon hydrolization of chlorogenic acid caffeic acid inhibits a number of lipoxygenases such as 5-LO (5-lipoxygenase), in a non-competitive manner, and 12-LO (12-lipoxygenase) inhibiting leukotriene synthesis resulting in further inhibition of immunoregulation. Caffeic Acid has also been shown to inhibit arachidonic acid metabolism in platelets at high doses. It has been observed to stimulate prostaglandin synthesis at high doses. Caffeic Acid is an inhibitor of GST, ODC, Tyk and Xanthine Oxidase.
1. Koshihara, Y., et al. 1984. Biochim. Biophys. Acta. 792: 92-97. PMID: 6318834 2. Shureiqi, I., et al. 2000. J. Natl. Cancer Inst. 92: 1136-1142. PMID: 10904086 3. Okombi, S., et al. 2006. Bioorg. Med. Chem. Lett. 16: 2252-2255. PMID: 16442796 4. Rao, C.V., et al. 1993. Cancer Res. 53: 4182-4188. PMID: 8364913 5. Kohyama, N., et al. 1997. Biosci. Biotechnol. Biochem. 61: 347-350. PMID: 9058975 6. da Cunha, F.M., et al. 2004. Free Radic. Res. 38: 1241-1253. PMID: 15621702 7. Chung, T.W., et al. 2004. FASEB J. 18: 1670-1681. PMID: 15522912 8. Bailly, F., et al. 2005. Curr. Med. Chem. 12: 1811-1818. PMID: 16029149 9. Kang, N.J., et al. 2009. Carcinogenesis. 30: 321-330. PMID: 19073879
Soluble in DMSO (40 mg/mL), ethanol (25 mg/mL warm), DMF (~7 mg/mL), PBS, PH 7.2 (~0.65 mg/mL), hot water, ethyl acetate, Chloroform Hexane, and methanol.
Store at room temperature
211-213° C (dec.)
~416.8° C at 760 mmHg (Predicted)
~1.5 g/cm3 (Predicted)
5-LO: IC50 = 3.7 µM; 12-LO: IC50 = 5.1-30 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Download SDS (MSDS)
Certificate of Analysis
Adobe Acrobat Reader is required to reliably view, print and comment on PDF documents
What is the appearance of the compound?
Asked by: two2igm05
Thank you for your question. The compound, sc-200499, is provided as a bright yellow powder. if you have any further questions or concerns, please feel free to contact our Technical Service department by calling 800-457-3801 option 2, emailing email@example.com, or using the Live Chat function on our website.
Rated 5 out of
Date published: 2016-11-19
Rated 5 out of
Kang et alKang et al. (PubMed ID 19073879) found that Caffeic Acid inhibited UVB-induced COX-2 expression by blocking Fyn kinase activity in JB6 P+ mouse skin epidermal (JB6 P+) cells. -SCBT Publication Review
To place an order using RMB or to ship to mainland China, please visit www.scbio.cn
Create a new account
Email address already exists, please enter a new valid email address.
USE YOUR SOCIAL NETWORK
Create an account quickly and easily with your preferred social network account. You won't have to remember an extra name and password.
Creating an account with us makes your shopping experience much easier and faster. You can save favorites, save cart, check order status and speed through checkout with saved addresses, payment methods and more.