CabergolineA D2-like agonist

Cabergoline (CAS 81409-90-7)

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Synonym: Cabaser; Dostinex; (8β)-N-[3-(Dimethylamino)propyl]-N-[(ethylamino)carbonyl]-6-(2-propen-1-yl)-ergoline-8-carboxamide
Application: A D2-like agonist
CAS Number: 81409-90-7
Purity: ≥98%
Molecular Weight: 451.60
Molecular Formula: C26H37N5O2
* Refer to Certificate of Analysis for lot specific data (including water content).
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Cabergoline is a selective D2DR (D2-like receptor) agonist, similarly displaying a high affinity for several serotonin receptor subtypes. Cabergoline exhibits an inhibitory effect of the secretion of prolactin and growth hormone and has been shown to reverse levodopa-induced dyskinesias in Parkinsonian monkeys. Cabergoline is an activator of D3DR.


References

Eguchi et al (1995) Effect of cabergoline, a dopamine agonist, on estrogen-induced rat pituitary tumors:in vitro culture studies. Endocr.J. 42 413. Hadj Tahar et al (2000) Sustained cabergoline treatment reverses levodopa-induced dyskinesias in parkinsonian monkeys. Cin.Neuropharmacol. 23 195. Kvernmo et al (2006) A review of the receptor-binding and pharmacokinetic properties of dopamine agonists. Clin.Ther. 28 1065.

Physical State :
Solid
Solubility :
Soluble in water (partly miscible), DMSO (100 mM ), ethanol (100 mM), chloroform, and methanol.
Storage :
Store at 4° C
Melting Point :
102-104° C
Boiling Point :
655.73° C (Predicted)
Density :
1.16 g/cm3 (Predicted)
Refractive Index :
n20D 1.59 (Predicted)
Ki Data :
D2 receptor: Ki= 0.7 nM; D3 receptor: Ki= 1.5 nM; D4 receptor: Ki= 9.0 nM; D5 receptor: Ki= 165 nM
pK Values :
pKa: 13.05 (Predicted), pKb: 9.41 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
KE6167600
PubChem CID :
54746
MDL Number :
MFCD00867887
Beilstein Registry :
6020775
SMILES :
CCNC(=O)N(CCCN(C)C)C(=O)[C@@H]1C[C@H]2[C@@H](CC3=CNC4=CC=CC2=C34)N(C1)CC=C

Download SDS (MSDS)

Certificate of Analysis

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