CAA0225 A cathepsin L inhibitor

CAA0225

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Synonym: Cathepsin L Inhibitor
Application: A cathepsin L inhibitor
Purity: ≥95%
Molecular Weight: 487.55
Molecular Formula: C28H29N3O5
* Refer to Certificate of Analysis for lot specific data (including water content).
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CAA0225 is an epoxysuccinyl peptide and highly selective rat liver cathepsin L inhibitor (IC50 = 1.9 nM), while exhibiting little to no effect on rat liver cathepsin B at concentrations higher than 1000-5000 nM, in vitro. During autophagy, it has been shown through immunoblotting that CAA0225 (10 µg/ml) effectively inhibits the degradation of LC3-II and GABARAP compared to control, in nutrient-deprived HeLa and Huh-7 cells.

Physical State :
Solid
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
50909779
SMILES :
C1=CC=C(C=C1)C[C@@H](C(=O)NCC2=CC=CC=C2)NC(=O)[C@@H]3[C@H](O3)C(=O)NCCC4=CC=C(C=C4)O

Download SDS (MSDS)

Certificate of Analysis

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