c-Abl Inhibitors for functional analysis of cellular responses to c-Abl
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Labware ships FedEx Ground free of charge to the contiguous US
The Abl oncogene was initially identified as the viral transforming gene of Abelson murine leukemia virus (A-MuLV). The major translational product of c-Abl has been identified as a protein with tyrosine kinase activity and an SH2 domain. The Abl oncogene is implicated in several human leukemias including 90-95% of chronic myelocytic leukemia (CML), 20-25% of adult acute lymphoblastic leukemia (ALL) and 2-5% of pediatric ALL. In these leukemias the c-Abl proto-oncogene undergoes a (9;22) chromosomal translocation producing the Philadelphia (Ph1) chromosome. The molecular consequence of this trans-location is the generation of a chimeric Bcr/c-Abl mRNA encoding activated Abl protein-tyrosine kinase. The Bcr gene has been shown to encode a GTPase-activating protein (GAP) specific for the Ras-related GTP-binding protein, p21rac.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PMID: # 26603102 Contreras, PS. et al. 2016. Neuronal gene repression in Niemann-Pick type C models is mediated by the c-Abl/HDAC2 signaling pathway. Biochim. Biophys. Acta. 1859: 269-79.
PMID: # 25450971 Bernusso, VA. et al. 2015. Imatinib restores VASP activity and its interaction with Zyxin in BCR-ABL leukemic cells. Biochimica et biophysica acta. 1853: 388-95.
PMID: # 24569990 Wie, SM. et al. 2014. Inhibiting tyrosine phosphorylation of protein kinase Cδ (PKCδ) protects the salivary gland from radiation damage. J. Biol. Chem.. 289: 10900-10908.
PMID: # 23894305 Liu, Y. et al. 2013. Low expression of miR-196b enhances the expression of BCR-ABL1 and HOXA9 oncogenes in chronic myeloid leukemogenesis. PLoS ONE. 8: e68442.
PMID: # 22665498 Wetzel, D.M. et al. 2012. The Abl and Arg kinases mediate distinct modes of phagocytosis and are required for maximal Leishmania infection. Molecular and cellular biology. 32: 3176-86.
PMID: # 22475343 Dinis, J. et al. 2012. DNA damage response in imatinib resistant chronic myeloid leukemia K562 cells. Leukemia & lymphoma. 53: 2004-14.
PMID: # 22898604 Goussetis, DJ. et al. 2012. Autophagic degradation of the BCR-ABL oncoprotein and generation of antileukemic responses by arsenic trioxide. Blood. 120: 3555-62.
PMID: # 21690296 Chen A et al. 2011. c-Abl-Mediated Tyrosine Phosphorylation of the T-bet DNA-Binding Domain Regulates CD4+ T-Cell Differentiation and Allergic Lung Inflammation.
Mol Cell Biol. . 31: 3445-3456.
PMID: # 20717963 Chen, JY. et al. 2011. Bcr-Abl-induced tyrosine phosphorylation of Emi1 to stabilize Skp2 protein via inhibition of ubiquitination in chronic myeloid leukemia cells. J. Cell. Physiol.. 226: 407-413.
PMID: # 21386967 Vilas-Zornoza, A. et al. 2011. Frequent and simultaneous epigenetic inactivation of TP53 pathway genes in acute lymphoblastic leukemia. PLoS ONE. 6: -.
How can c-Abl Antibody (24-11): sc-23 mouse monoclonal antibody be used for double or triple staining, if the other primary antibodies are also raised in mouse?
Asked by: AbPolly
In this case, we recommend using a directly conjugated mouse monoclonal primary antibody. Please contact our Special Orders department for availability of direct conjugates, or see c-Abl (8E9): sc-56887 for c-Abl antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488 and Alexa Fluor® 647.
Answered by: Technical Support 7
Date published: 2017-01-10
Will this antibody detect c-Abl of bovine origin?
Asked by: AbPolly
Please contact our Technical Service Department and we would be happy to perform sequence analysis and review our data to answer any questions you may have about additional species reactivity.
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