Butyrolactone 3 A histone acetyltransferase GCN5 inhibitor

Butyrolactone 3 (CAS 778649-18-6)

Butyrolactone 3 | CAS 778649-18-6 is rated 5.0 out of 5 by 1.
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Synonym: MB-3; (2S,3R)-4-methylidene-5-oxo-2-propyloxolane-3-carboxylic acid; Gcn5 Inhibitor 1; 3-Methylene-4-hydroxycarbonyl-5-(1-propyl)-tetrahydrofuran-2-one
Application: A histone acetyltransferase GCN5 inhibitor
CAS Number: 778649-18-6
Purity: ≥95%
Molecular Weight: 184.19
Molecular Formula: C9H12O4
* Refer to Certificate of Analysis for lot specific data (including water content).
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Butyrolactone 3, also called MB-3 is an inhibitor of Histone acetyltransferase GCN5 (general control of amino-acid synthesis 5). Gcn5 HAT activity is required to acetylate histone H3 lysine 9 (K9) and K14, which allows transcription elongation by relaxing nucleosomes. Butyrolactone 3 specifically inhibits Gcn5's HAT activity. It has been shown to display anti-inflammatory and anti-carcinogenic effects.


References

1. Mai, Antonello., et al., 2006. Small-molecule inhibitors of histone acetyltransferase activity: identification and biological properties. Journal of medicinal chemistry. 49(23): 6897-907. PMID: 17154519
2. Holmlund, T., et al., 2013. GCN5 acetylates and regulates the stability of the oncoprotein E2A-PBX1 in acute lymphoblastic leukemia. Leukemia. 27(3): 578-85. PMID: 23044487

Physical State :
Solid
Solubility :
Soluble in DMSO, and methanol.
Storage :
Store at -20° C
Melting Point :
60° C
Boiling Point :
386.21° C at 760 mmHg (Predicted)
Density :
1.20 g/cm3 (Predicted)
Refractive Index :
n20D 1.50 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
10081070
MDL Number :
MFCD08702690
SMILES :
CCC[C@H]1[C@@H](C(=C)C(=O)O1)C(=O)O

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Butyrolactone 3  Product Citations

See how others have used Butyrolactone 3. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 26162318  Tan, CS. et al. 2015. Molecular neurobiology.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Holmlund et al Holmlund et al. (PubMed ID 23044487) found that Butyrolactone 3 inhibited GCN5 and decreased E2A-PBX1 acetylation and E2A-PBX1 protein levels in leukemic cells. -SCBT Publication Review
Date published: 2015-03-28
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