BTZO 1 is a suppressor of cardiomyocyte apoptosis presumably by activation of antioxidant response element (ARE)-mediated gene expression. BTZO-1 binds to the macrophage migration inhibitory factor (MIF) that is required to activate the glutathione S-transferase Ya subunit (GST Ya) gene ARE.
1. Kimura, H. et al. 2010. Chem. Biol. 17(12): 1282-1294. PMID: 21168764
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