BRL-37344A potent and selective β3-AR agonist

BRL-37344 (CAS 127299-93-8)

BRL-37344 | CAS 127299-93-8 is rated 5.0 out of 5 by 1.
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Synonym: BRL-37344 Sodium Salt
Application: A potent and selective β3-AR agonist
CAS Number: 127299-93-8
Purity: 98%
Molecular Weight: 385.82
Molecular Formula: C19H21ClNO4•Na
* Refer to Certificate of Analysis for lot specific data (including water content).
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BRL-37344 is a β3-AR (β 3-adrenoceptor) selective agonist with lipolytic activity. The β 3 receptor has been reported to have a high affinity towards BRL-37344. Studies show that BRL-373344 promotes thermogenesis and its RR enantiomer acts as a stronger agonist in brown adipocytes in comparison to white adipocytes. Analysis of BRL-37344, isoproterenol, and norepinephrine showed BRL-37334 to be the most potent agonist. BRL-37344 is an activator of β2-AR and β1-AR.


References

1. Forest, C., et al. 1987. Exp. Cell Res. 168: 218-232. PMID: 2877896
2. Muzzin, P., et al. 1991. J. Biol. Chem. 266: 24053-24058. PMID: 1721063
3. Granneman, J.G., et al. 1991. Mol. Pharmacol. 40: 895-899. PMID: 1684635
4. Murphy, G.J., et al. 1993. Biochem. Pharmacol. 46: 575-581. PMID: 8103324
5. Zhao, J., et al. 1994. Am. J. Physiol. 267: C969-C979. PMID: 7943293
6. Oriowo, M.A., et al. 1996. J. Pharmacol. Exp. Ther. 277: 22-27. PMID: 8613923

Physical State :
Solid
Solubility :
Soluble in water (100 mM).
Storage :
Store at room temperature
Melting Point :
228-230° C
Ki Data :
β3 receptor: Ki= 287 nM; β1 receptor: Ki= 1750 nM; β2 receptor: Ki= 1120 nM
pK Values :
pKa: 3.18 (Predicted), pKb: 8.98 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
16219010
SMILES :
C[C@H](CC1=CC=C(C=C1)OCC(=O)[O-])NC[C@@H](C2=CC(=CC=C2)Cl)O.[Na+]

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BRL-37344  Product Citations

See how others have used BRL-37344. Click on the entry to view the PubMed entry .

Citations 1 to 3 of 3 total

PMID: # 28578076  Shimamoto, S. et al. 2017. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. 211: 1-6.

PMID: # 16492754  Carlin, KM. et al. 2006. Proc. Natl. Acad. Sci. U.S.A. 103: 3462-3467.

PMID: # 14983038  Bing, C. et al. 2004. Proc. Natl. Acad. Sci. USA. 101: 2500-5.

Citations 1 to 3 of 3 total
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Rated 5 out of 5 by from Carlin et al Carlin et al. (PubMed ID 16492754) used the 3 agonist, BRL-37344, to increase mice interscapular brown adipose tissue (IBAT) temperature. -SCBT Publication Review
Date published: 2015-02-06
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