Brefeldin A is a fungal metabolite that disrupts the structure and function of the Golgi apparatus. The compound induces the Golgi proteins to redistribute into the ER and blocks the secretion from the Golgi apparatus. Studies show that it blocks the GTP-dependent interaction of ARF with the Golgi membrane, thus inhibiting the assembly of coatomer onto the membrane. Research shows that Brefeldin A can induce apoptosis in Neuroendocrine tumor cells by activating caspase-3, and inhibits cell growth by targeting the cell cycle in prostate cancer cells. Brefeldin A is an inhibitor of ARF.
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Eupenicillum sp. UN88
Soluble in water (Partly miscible), methanol (10 mg/mL), ethanol (5 mg/mL), DMSO (20 mg/mL), acetone, and ethyl acetate (1 mg/mL).
Store at -20° C
~492.7° C at 760 mmHg (Predicted)
~1.1 g/cm3 (Predicted)
α20/D 96°±2° in methanol; α20/D 93°, c = 2 in methanol
Hi, I'm interested in buying Brefeldin A (sc-200861). The product would be received in USA by a colleague. Can you make an invoice with an argentinean billing adress? Thank you.
Asked by: augustob
Thank you for your question. Yes, we can process your order with a U.S. shipping address and an Argentinian billing address. Please contact our Customer Care Department to place your order or request a quote. Please call us toll-free at (800) 457-3801 option 1, e-mail <firstname.lastname@example.org>, or use the live chat on our website.
Answered by: Technical Support
Date published: 2017-11-07
What is the appearance of the compound?
Asked by: two2igm05
Thank you for your question. This chemical, sc-200861, is provided as a white to off-white crystalline powder. If you have any further questions or concerns, please feel free to contact our Technical Service department by calling 800-457-3801 option 2, emailing email@example.com, or using the Live Chat function on our website.
Rated 4 out of
Brefeldin A works wellThis product worked well in human cell lines, we pre-treated the cells for 1 h at 37 C and treated with our samples
Date published: 2018-08-04
Rated 5 out of
Found to downregulate the expression of ARFound to downregulate the expression of AR in LNCaP cells. Decrease in protein expression observed by WB comparing cells that were untreated with those that have been treated with brefeldin A. -SCBT QC
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