BpV(pic) is composed of a vanadate molecule coordinated to picolinic acid (2-carboxypyridine) and potassium, that is thought to act as an insulin mimetic. This compound has been shown to activate the insulin receptor kinase (IRK) of cultured hepatoma cells, stimulate lipogenesis in adipocytes, and inhibit the dephosphorylation of autophosphorylated insulin receptors and epidermal growth factor receptors of rat liver endosomes. bpV(pic) is also an inhibitor of G6Pase and PTP, and an activator of insulin R.
1. Posner, B.I., et al. 1994. J. Biol. Chem. 269: 4596-4604. PMID: 8308031
See how others have used bpV(pic). Click on the entry to view the PubMed entry .
PMID: # 26550415
Guan, Y. et al. 2015. Impacts of phosphatase and tensin homology deleted on chromosome ten (PTEN)-inhibiting chitosan scaffold on growth and differentiation of neural stem cells. Int J Clin Exp Med. 8: 14308-15.
PMID: # 23934019
2013. Attempted application of bioengineered/biosynthetic supporting matrices with phosphatidylinositol-trisphosphate-enhancing substances to organ culture of human primordial follicles. J. Assist. Reprod. Genet.. 30: 1279-88.
PMID: # 22561198
Christie, KJ. et al. 2012. Disruption of E3 ligase NEDD4 in peripheral neurons interrupts axon outgrowth: Linkage to PTEN. Mol. Cell. Neurosci.. 50: 179-92.
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