BpV(pic) is composed of a vanadate molecule coordinated to picolinic acid (2-carboxypyridine) and potassium, that is thought to act as an insulin mimetic. This compound has been shown to activate the insulin receptor kinase (IRK) of cultured hepatoma cells, stimulate lipogenesis in adipocytes, and inhibit the dephosphorylation of autophosphorylated insulin receptors and epidermal growth factor receptors of rat liver endosomes. bpV(pic) is also an inhibitor of G6Pase and PTP, and an activator of insulin R.
1. Posner, B.I., et al. 1994. J. Biol. Chem. 269: 4596-4604. PMID: 8308031
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bpV(pic) was found to inhibit the actionbpV(pic) was found to inhibit the action of lambda protein phosphatase. This was demonstrated by IF showing nuclear localization and increase in signal of phosphorylated NFkB p50 in the treated HeLa cells. -SCBT QC
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