bpV(pic) A potent protein PTP inhibitor

bpV(pic) (CAS 148556-27-8)

bpV(pic) | CAS 148556-27-8 is rated 5.0 out of 5 by 1.
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| See product citations (3)
Synonym: Dipotassium bisperoxo (picolinato) oxovanadate (V)
Application: A potent protein PTP inhibitor
CAS Number: 148556-27-8
Purity: ≥90%
Molecular Weight: 367.28
Molecular Formula: K2[VO(O2)2C6H4NO2]•2H2O
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ordering Information

PRODUCT NAME CATALOG # UNIT PRICE QTY FAVORITES
bpV(pic) sc-221379 5 mg $84.00
bpV(pic) sc-221379A 25 mg $321.00

BpV(pic) is composed of a vanadate molecule coordinated to picolinic acid (2-carboxypyridine) and potassium, that is thought to act as an insulin mimetic. This compound has been shown to activate the insulin receptor kinase (IRK) of cultured hepatoma cells, stimulate lipogenesis in adipocytes, and inhibit the dephosphorylation of autophosphorylated insulin receptors and epidermal growth factor receptors of rat liver endosomes. bpV(pic) is also an inhibitor of G6Pase and PTP, and an activator of insulin R.


References

1. Posner, B.I., et al. 1994. J. Biol. Chem. 269: 4596-4604. PMID: 8308031

Physical State :
Solid
Solubility :
Soluble in water (3 mg/ml), and DMSO.
Storage :
Store at 4° C
IC50 :
PTEN: IC50 = 31 nM; PTP- β: IC50 = 12.7 µM; PTP-1 βB: IC50 = 61 µM
Ki Data :
Glucose-6-phosphatase : Ki= 0.42 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
16760324
SMILES :
O=C1[O-][V+3]23([N]4=CC=CC=C41)([O-][O-]2)([O-][O-]3)=O.[K+].[K+].O.O

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bpV(pic)Product Citations

See how others have used bpV(pic). Click on the entry to view the PubMed entry .

Citations 1 to 3 of 3 total

PMID: # 26550415
Guan, Y. et al. 2015. Impacts of phosphatase and tensin homology deleted on chromosome ten (PTEN)-inhibiting chitosan scaffold on growth and differentiation of neural stem cells. Int J Clin Exp Med. 8: 14308-15.

PMID: # 23934019
2013. Attempted application of bioengineered/biosynthetic supporting matrices with phosphatidylinositol-trisphosphate-enhancing substances to organ culture of human primordial follicles. J. Assist. Reprod. Genet.. 30: 1279-88.

PMID: # 22561198
Christie, KJ. et al. 2012. Disruption of E3 ligase NEDD4 in peripheral neurons interrupts axon outgrowth: Linkage to PTEN. Mol. Cell. Neurosci.. 50: 179-92.

Citations 1 to 3 of 3 total
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Rated 5 out of 5 by from bpV(pic) was found to inhibit the action bpV(pic) was found to inhibit the action of lambda protein phosphatase. This was demonstrated by IF showing nuclear localization and increase in signal of phosphorylated NFkB p50 in the treated HeLa cells. -SCBT QC
Date published: 2015-01-04
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