BpV(pic) is composed of a vanadate molecule coordinated to picolinic acid (2-carboxypyridine) and potassium, that is thought to act as an insulin mimetic. This compound has been shown to activate the insulin receptor kinase (IRK) of cultured hepatoma cells, stimulate lipogenesis in adipocytes, and inhibit the dephosphorylation of autophosphorylated insulin receptors and epidermal growth factor receptors of rat liver endosomes. bpV(pic) is also an inhibitor of G6Pase and PTP, and an activator of insulin R.
1. Posner, B.I., et al. 1994. J. Biol. Chem. 269: 4596-4604. PMID: 8308031
See how others have used bpV(pic). Click on the entry to view the PubMed entry .
PMID: # 26550415 Guan, Y. et al. 2015. Int J Clin Exp Med. 8: 14308-15.
PMID: # 23934019 2013. J. Assist. Reprod. Genet. 30: 1279-88.
PMID: # 22561198 Christie, KJ. et al. 2012. Mol. Cell. Neurosci. 50: 179-92.
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