Borrelidin An anti-angiogenic and anti-microbial compound

Borrelidin (CAS 7184-60-3)

Borrelidin | CAS 7184-60-3 is rated 5.0 out of 5 by 1.
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Synonym: Quinquangulin K 031; Quinquangulin K 182; oxacyclooctadeca-4, 6-dien-2-yl)-
Application: An anti-angiogenic and anti-microbial compound
CAS Number: 7184-60-3
Purity: 98%
Molecular Weight: 489.64
Molecular Formula: C28H43NO6
* Refer to Certificate of Analysis for lot specific data (including water content).
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Borrelidin is derived from Streptomyces rochei and has anti-angiogenic and anti-microbial activity. The compound has been shown to inhibit both eukaryal and bacterial threonyl-tRNA synthetase (ThrRS). It also stimulate apoptosis of tube-forming cells in capillary tubes with the activation of caspase-3 and caspase-8. Research shows that Borreldin also disrupts formed capillary tubes and inhibits proliferation of human umbilical vein endothelial cell (HUVEC) proliferation. Borrelidin is an inhibitor of Cdk.


References

1. Wakabayashi, T., et al. 1997. J. Antibiot. 50: 671-677. PMID: 9315080
2. Kawamura, T. , et al. 2003. J. Antibiot. 56: 709. PMID: 14563161
3. Ruan, B., et al. 2005. J. Biol. Chem. 280: 571-577. PMID: 15507440

Physical State :
Solid
Solubility :
Soluble in ethanol, methanol (1 mg/ml), DMSO (1 mg/ml), DMF, and ethyl acetate.
Storage :
Store at -20° C
Boiling Point :
710.30° C at 760 mmHg (Predicted)
Density :
1.15 g/cm3 (Predicted)
Refractive Index :
n20D 1.54 (Predicted)
IC50 :
Cyclin-dependent kinase Cdc28/Cln2: IC50 = 24 µM; Antiangiogenic activity: IC50 = 0.8 nM; HUVEC50 (Umbilical vein endothelial cells): IC50 = 0.5 nM (human); Antiproliferative activity against NCI60 cell line: IC50 = 20 nM
pK Values :
pKa: 4.56 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
ED8750000
PubChem CID :
23724539
MDL Number :
MFCD01740784
SMILES :
C[C@H]1C[C@H](C[C@@H]([C@H](/C(=C\C=C\C[C@@H](OC(=O)C[C@@H]([C@H](C1)C)O)[C@@H]2CCC[C@H]2C(=O)O)/C#N)O)C)C

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Certificate of Analysis

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Borrelidin  Product Citations

See how others have used Borrelidin. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 28379541  Aslani, F. et al. 2017. Mol. Hum. Reprod. 23: 370-380.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Mirando AC; et al Mirando AC; et al. (PubMed ID: 26271225) determined that Borrelidin's mechansim of action is linked to its competition with the threonine substrate, which increases amino acid starvation and apoptosis. -SCBT Publication Review
Date published: 2015-05-05
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