Bongkrekic acid is a mitochondrial permeability transition pore blocker that acts as an inhibitory ligand of the mitochondrial adenine nucleotide translocator. This compound has been shown to inhibit apoptosis by preventing PARP cleavage and DEVDase activity.
1. Yoon, H.S., et al. 2000. Biochem Bioph Res Comun. 276:151-156. PMID: 11006098 2. Zamora, M., et al. 2004. FEBS Letters. 563:155-160. PMID: 15063741
Soluble in NH4OH (2N ), DMSO (100 mg/ml), and water.
Store at -20° C
n20D 1.55 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Zamora et alZamora et al. (PubMed ID 15063741) used bongkrekic acid to inhibit mitochondrial adenine nucleotide translocase 3 (ANT3)-mediated apoptosis in cultured cells. -SCBT Publication Review
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