Bongkrekic acid An apoptosis inhibitor through prevention of PARP cleavage

Bongkrekic acid (CAS 11076-19-0)

Bongkrekic acid | CAS 11076-19-0 is rated 5.0 out of 5 by 1.
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Synonym: Bongkrek acid; Flavotoxin A
Application: An apoptosis inhibitor through prevention of PARP cleavage
CAS Number: 11076-19-0
Purity: ≥98%
Molecular Weight: 537.69
Molecular Formula: C28H38O73NH3
* Refer to Certificate of Analysis for lot specific data (including water content).
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Bongkrekic acid is a mitochondrial permeability transition pore blocker that acts as an inhibitory ligand of the mitochondrial adenine nucleotide translocator. This compound has been shown to inhibit apoptosis by preventing PARP cleavage and DEVDase activity.


References

1. Yoon, H.S., et al. 2000. Biochem Bioph Res Comun. 276:151-156. PMID: 11006098
2. Zamora, M., et al. 2004. FEBS Letters. 563:155-160. PMID: 15063741

Physical State :
Solid
Solubility :
Soluble in NH4OH (2N ), DMSO (100 mg/ml), and water.
Storage :
Store at -20° C
Melting Point :
50-60° C
Refractive Index :
n20D 1.55 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Merck Index :
14: 1332
MDL Number :
MFCD02179190
SMILES :
CC(CC=CCCC=CC=CCC(C(=CC=C(C)C(=O)O)C)OC)C=CC(=CC(=O)O)CC(=O)O.N.N.N

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Certificate of Analysis

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Rated 5 out of 5 by from Zamora et al Zamora et al. (PubMed ID 15063741) used bongkrekic acid to inhibit mitochondrial adenine nucleotide translocase 3 (ANT3)-mediated apoptosis in cultured cells. -SCBT Publication Review
Date published: 2015-04-01
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