Boc-L-aspartic acid beta-benzyl ester chloromethylketone is cell penetrable. This inhibitor has been shown to bind covalently to the active site of ICE, reducing ICE-mediated processing of mature interleukin-1β in a monocytic cell line without affecting tumor necrosis factor processing.
1. Boudreau, N., et al., 1995. Suppression of ICE and apoptosis in mammary epithelial cells by extracellular matrix. Science (New York, N.Y.). 267(5199): 891-3. PMID: 7531366
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