BML-267A potent and selective protein tyrosine phosphatase 1B (PTP1B) inhibitor

BML-267

BML-267 is rated 5.0 out of 5 by 1.
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Synonym: 6-Methyl-2-(oxalylamino)-4,5,6,7-tetrahydrothieno[2, 3-c]pyridine-3-carboxylic acid trifluoroacetic acid salt
Application: A potent and selective protein tyrosine phosphatase 1B (PTP1B) inhibitor
Purity: ≥95%
Molecular Weight: 398.31
Molecular Formula: C11H12N2O5S•C2HF3O2
* Refer to Certificate of Analysis for lot specific data (including water content).
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BML-267 is a potent and selective PTP1B (protein tyrosine phosphatase 1B) inhibitor (IC50=11 μM)1. A similar N-des-methyl analog has been reported and has been used to probe the mechanism of PTP1B-mediated inhibition of leptin signaling. BML-267 have limited cell permeability. A cell permeable diethyl ester prodrug of BML-267 compound is available.


References

1. Iversen, L.F., et al. 2000. J. Biol. Chem. 275: 10300-10305. PMID: 10744717
2. Andersen, H.S., et al. 2002. J. Med. Chem. 45: 4443-4459. PMID: 12238924
3. Lund, I.K., et al. 2005. J. Mol. Endocrinol. 34: 339-351. PMID: 15821101

Physical State :
Solid
Solubility :
Soluble in: DMSO 10 mg/mL
Storage :
Store at -20° C
IC50 :
protein tyrosine phosphatase 1B (PTP1B): IC50 = 11 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
SMILES :
OC(=O)C(F)(F)F.CN1CCC2=C(C1)SC(=C2C(=O)O)NC(=O)C(=O)O

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Arrived quickly Arrived quickly, worked well in my experiments, satisfied with products
Date published: 2015-05-04
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