Bleomycin Sulfate A glycopeptide antibiotic

Bleomycin Sulfate (CAS 9041-93-4)

Bleomycin Sulfate | CAS 9041-93-4 is rated 5.0 out of 5 by 3.
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Synonym: Blenoxane
Application: A glycopeptide antibiotic
CAS Number: 9041-93-4
Purity: ≥90%
Molecular Weight: 1512
Molecular Formula: C55H84N17O21S3•H2SO4
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Bleomycin sulfate is the sulfate salt of a complex natural product antibiotic. This compound approximates metals such as Fe(II) which then coordinate dioxygen to generate the active species. This Bleomycin-metal-dioxygen species is capable of inducing oxidative cleavage of the DNA backbone, leading to apoptosis. The species also degrades RNA, and has been reported to display selectivity for RNA over DNA.


References

1. Petering, D.H., et al. 1990. Chem. Biol. Interact. 73: 133-182. PMID: 1690086
2. Hüttenhofer, A., et al. 1992. J. Biol. Chem. 267: 24471-24475. PMID: 1280260
3. Holmes, C.E., et al. 1997. Bioorg. Med. Chem. 5: 1235-1248. PMID: 9222517

Appearance :
Powder
Physical State :
Solid
Derived From :
Streptomyces sp. MST-AS4458
Solubility :
Soluble in water (20 mg/ml), methanol, moderate ethanol , PBS (pH 7.2) (10 mg/ml), DMF (2 mg/ml), and DMSO (13 mg/ml).
Storage :
Store at -20° C
Melting Point :
200-204° C (dec.)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
EC5991990
PubChem CID :
131664136
Merck Index :
14: 1318
MDL Number :
MFCD00070310
EC Number :
232-925-2
SMILES :
CC1=C(N=C(N=C1N)C(CC(=O)N)NCC(C(=O)N)N)C(=O)NC(C(C2=CN=CN2)OC3C(C(C(C(O3)CO)O)O)OC4C(C(C(C(O4)CO)O)OC(=N)[O-])O)C(=O)NC(C)C(C(C)C(=O)NC(C(C)O)C(=O)NCCC5=NC(=CS5)C6=NC(=CS6)C(=O)NCCC[S+](C)C)O.OS(=O)(=O)O

Download SDS (MSDS)

Certificate of Analysis

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Bleomycin Sulfate  Product Citations

See how others have used Bleomycin Sulfate. Click on the entry to view the PubMed entry .

Citations 1 to 10 of 13 total

PMID: # 28265008  Liu, CW. et al. 2017. Mol. Cancer Ther. 16: 1421-1434.

PMID: # 27869163  Schrock, MS. et al. 2016. Oncogene.

PMID: # 25837271  2015. Phytomedicine. 22: 344-51.

PMID: # 25483091  Cui, Y. et al. 2014. Cell cycle (Georgetown, Tex.). 13: 3541-50.

PMID: # 23485585  Myers, JM. et al. 2013. Free Radic. Biol. Med. 60: 183-94.

PMID: # 18245174  Yu, H. et al. 2008. FASEB J. 22: 1778-1789.

PMID: # 16251407  Walters, DM. et al. 2005. Am. J. Pathol. 167: 1221-1229.

PMID: # 12754187  Marshall, RP. et al. 2004. Am. J. Physiol. Lung Cell Mol. Physiol. 286: L156-L164.

PMID: # 10637286  Baber-Furnari, BA. et al. 2000. Mol. Biol. Cell. 11: 1-1-1111.

PMID: # 10734156  Gurujeyalakshmi, G. et al. 2000. J. Pharmacol. Exp. Ther. 293: 82-90.

Citations 1 to 10 of 13 total

I ordered this compound: Bleomycin Sulfate, 10 mg sc-200134 I would like to have some more information about it: Does this product contain only the Bleomycin A2, or is a mixture of A2 and B2?

Asked by: Matteo
Thank you for your question. This biochemical, sc-200134, contains a mixture. The exact mixture make-up is lot dependent, but the most recent lot contains the following. B4: 0.2% A2+B2: ≥ 92.5%
Answered by: Tech Service
Date published: 2019-07-01

Is this substance pharmaceutical grade and what's the purity of this compound?

Asked by: Nupur
This compound is not pharmaceutical grade, it is for research use only. Each lot of this chemical comes with a lot-specific Certificate Of Analysis which typically describes the percent purity as well as the method used to determine the purity. You may request a lot-specific Certificate Of Analysis on our website. Alternatively, please contact our Technical Service Department to inquire about the purity of our most recent lot.
Answered by: Technical Support
Date published: 2019-01-26

We failed to find to correct dose of Bleomycin Sulphate for the murine model of bleomycin-induced lung fibrosis. What do you advice? How to calulate the doses in Units, International Units and mg? Could you help us? thanks

Asked by: mc5821
Thank you for the question. You might want to consult PubMed ID# 18245174 or the other currently listed 11 references we list for this compound.
Answered by: Technical Support Europe
Date published: 2018-01-09

After resuspension, what is the ideal storage temperature for the bleomycin sulfate solution?

Asked by: gargamel
Thank you for your question. We recommend to only prepare as much solution as you need at once time and to prepare fresh solutions for future use.
Answered by: Technical Support
Date published: 2017-11-08

Is it medical grade?

Asked by: chemsd02
Thank you for your question. sc-200134 (Bleomycin Sulfate, CAS 9041-93-4) is not offered in medical grade.
Answered by: Chemical Support 10
Date published: 2017-04-06

What is the appearance of the compound?

Asked by: two2igm05
Thank you for your question. The compound, sc-200134, is provided as a white to light yellow powder. If you have any further questions or concerns, please feel free to contact our Technical Service department by calling 800-457-3801 option 2, emailing scbt@scbt.com, or using the Live Chat function on our website.
Answered by: Tech Service 8
Date published: 2017-07-20
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Rated 5 out of 5 by from PMID 25837271 USED sc-200134 PMID 25837271 USED THIS PRODUCT. IT IS A VERY GOOD PRODUCT.
Date published: 2017-05-23
Rated 5 out of 5 by from A VERY GOOD PRODUCT I USED IT IN MY MANUSCRIPT. IT IS A VERY GOOD PRODUCT.
Date published: 2017-04-04
Rated 5 out of 5 by from Yu Yu, et. al. (PubMed ID 18245174) used bleomycin to induce lung fibrosis in mice. Also used to test whether Tagln expression would be augmented in ATII cells when treated with this antibiotic. -SCBT Publication Review
Date published: 2015-01-18
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