Blasticidin A An aflatoxin production inhibitor

Blasticidin A (CAS 100513-53-9)

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Application: An aflatoxin production inhibitor
CAS Number: 100513-53-9
Purity: ≥95%
Molecular Weight: 1186.5
Molecular Formula: C58H107NO23
* Refer to Certificate of Analysis for lot specific data (including water content).
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Blasticidin A, an antibiotic produced by Streptomyces, has been shown to have strong inhibitory activity toward aflatoxin production by Aspergillus parasiticus. This inhibition of aflatoxin production does not have a strong growth suppressing impact toward the aflatoxin-producing fungi. There was a decrease in abundance of ribosomal protein observed in Blasticidin A treated A. parasitici. Experiments indicate that Blasticidin A significantly reduced the expression of genes encoding aflatoxin regulatory gene and biosynthetic enzymes (omtA, ver-1, and pksA) in A. parasiticus.


References

1. Sakuda, S., et al. 2000. J. Antibiot. 53: 1265-1271. PMID: 11213287
2. Sakuda, S., et al. 2000. J. Antibiot. 53: 1378-1384. PMID: 11217803
3. Sakuda, S., et al. 2004. Biosci. Biotechnol. Biochem. 68: 407-412. PMID: 14981305
4. Yoshinari, T., et al. 2010. J. Antibiot. 63: 309-314. PMID: 20414321

Physical State :
Solid
Derived From :
Streptomyces sp.
Solubility :
Soluble in DMSO, DMF, methanol, water (Fairly soluble), and ethanol (Fairly soluble).
Storage :
Store at -20° C
Boiling Point :
1313.44° C at 760 mmHg (Predicted)
Density :
1.32 g/cm3 (Predicted)
Refractive Index :
n20D 1.58 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
EC4897000
PubChem CID :
6447788
MDL Number :
MFCD01770492
SMILES :
CCCCCCCCCCC(CC1(C(C(C(C(O1)CC(C(C(C(C(CC(CC(CC(CC(C(C)C(C(C)C(CC(C(C)C(C(CC(C)CC(C)/C=C(\\C)/C(=O)C2=C(N(CC2=O)C)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O

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Certificate of Analysis

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