Bis(methylthio)gliotoxin (FR-49175) is a toxic metabolite with anthiphagocytic and immunosuppressive properties synthesized by pathogenic fungi such as Aspergillus fumigatus. Bis(methylthio)gliotoxin (FR-49175) is an analog of gliotoxin known to inhibit PAF-induced platelet aggregation and collagen-aggregation, but has no activity with arachidonic or ADP induced aggregation. Shown to speed up PAF hydrolysis and inhibit PAF-mediated caspase 3 activation. From guinea-pig experiments, reported to Inhibit PAF-induced bronchoconstriction.
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See how others have used Bis(methylthio)gliotoxin (FR-49175). Click on the entry to view the PubMed entry .
PMID: # 16830893
Li, X. et al. 2006. A new antibacterial dioxopiperazine alkaloid related to gliotoxin from a marine isolate of the fungus Pseudallescheria. J. Antibiot.. 59: 248-250.
PMID: # 11374585
Woodcock, JC. et al. 2001. Metal complexes of sporidesmin D and dimethylgliotoxin, investigated by electrospray ionisation mass spectrometry. J. Inorg. Biochem.. 84: 225-232.
PMID: # 9933632
Ward, C. et al. 1999. NF-kappaB activation is a critical regulator of human granulocyte apoptosis in vitro. J. Biol. Chem.. 274: 4309-4318.
PMID: # 2457219
Yoshida, K. et al. 1988. PAF inhibitors of microbial origin. Studies on diketopiperazine derivatives. Prog Biochem Pharmacol. 22: 66-80.
PMID: # 2421924
Okamoto, M. et al. 1986. Studies of platelet activating factor (PAF) antagonists from microbial products. II. Pharmacological studies of FR-49175 in animal models. Chem. Pharm. Bull.. 34: 345-348.
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