Bis(methylthio)gliotoxin (FR-49175) is a toxic metabolite with anthiphagocytic and immunosuppressive properties synthesized by pathogenic fungi such as Aspergillus fumigatus. Bis(methylthio)gliotoxin (FR-49175) is an analog of gliotoxin known to inhibit PAF-induced platelet aggregation and collagen-aggregation, but has no activity with arachidonic or ADP induced aggregation. Shown to speed up PAF hydrolysis and inhibit PAF-mediated caspase 3 activation. From guinea-pig experiments, reported to Inhibit PAF-induced bronchoconstriction.
1. Pahl, H.L., et al. 1996. J. Exp. Med. 183: 1829-1840. PMID: 8666939
2. Bonin, F., et al. 2004. J. Biol. Chem. 279: 52425-52436. PMID: 15456758
3. Zhao, W.Y., et al. 2009. Nat. Prod. Res. 23: 203-207. PMID: 19235019
See how others have used Bis(methylthio)gliotoxin (FR-49175). Click on the entry to view the PubMed entry .
PMID: # 16830893
Li, X. et al. 2006. A new antibacterial dioxopiperazine alkaloid related to gliotoxin from a marine isolate of the fungus Pseudallescheria. J. Antibiot.. 59: 248-250.
PMID: # 11374585
Woodcock, JC. et al. 2001. Metal complexes of sporidesmin D and dimethylgliotoxin, investigated by electrospray ionisation mass spectrometry. J. Inorg. Biochem.. 84: 225-232.
PMID: # 9933632
Ward, C. et al. 1999. NF-kappaB activation is a critical regulator of human granulocyte apoptosis in vitro. J. Biol. Chem.. 274: 4309-4318.
PMID: # 2457219
Yoshida, K. et al. 1988. PAF inhibitors of microbial origin. Studies on diketopiperazine derivatives. Prog Biochem Pharmacol. 22: 66-80.
PMID: # 2421924
Okamoto, M. et al. 1986. Studies of platelet activating factor (PAF) antagonists from microbial products. II. Pharmacological studies of FR-49175 in animal models. Chem. Pharm. Bull.. 34: 345-348.
Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2017 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.