Bilobalide A compound with neuroprotective, antibacterial, and inhibitory effects

Bilobalide (CAS 33570-04-6)

Bilobalide | CAS 33570-04-6 is rated 5.0 out of 5 by 1.
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Synonym: (-)-Bilobalide
Application: A compound with neuroprotective, antibacterial, and inhibitory effects
CAS Number: 33570-04-6
Purity: ≥98%
Molecular Weight: 326.3
Molecular Formula: C15H18O8
* Refer to Certificate of Analysis for lot specific data (including water content).
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Bilobalide is a terpenoid extracted from ginkgo biloba leaves with potent protective effects on neurons and Schwann cells. It has also been discovered to inhibit the hypoxia-induced reduction of ATP and under normoxic conditions increase glucose transport. Bilobalide is a inhibitor of GABA Receptor and SR. Bilobalide is a activator of MB67.


References

1. Atzori, C., et al. 1993. Antimicrob. Agents Chemother. 37: 1492-1496. PMID: 8363381
2. Bruno, C., et al. 1993. Planta Med. 59: 302-307. PMID: 8372143
3. Janssens, D., et al. 1995. Biochem. Pharmacol. 50: 991-999. PMID: 7575684
4. Umegaki, K., et al. 2007. J. Pharm. Pharmacol. 59: 871-877. PMID: 17637180
5. Brown, M.K. 2009. BMC Neurosci. 10: 62. PMID: 19545409
6. Shi, C., et al. 2010. Apoptosis. 15: 715-727. PMID: 20333467

Physical State :
Solid
Solubility :
Soluble in ethanol(warm) (25 mg/ml), DMSO(warm) (25 mg/ml), and water (<1 mg/ml).
Storage :
Store at -20° C
Boiling Point :
651.74° C at 760 mmHg (Predicted)
Density :
1.56 g/cm3 (Predicted)
Refractive Index :
n20D 1.61 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
73581
MDL Number :
MFCD00238547
SMILES :
CC(C)(C)[C@@]1(C[C@H]2[C@@]3([C@]14[C@H](C(=O)O[C@H]4OC3=O)O)CC(=O)O2)O

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Certificate of Analysis

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Bilobalide  Product Citations

See how others have used Bilobalide. Click on the entry to view the PubMed entry .

Citations 1 to 3 of 3 total

PMID: # 19937548  Madgula, VL. et al. 2010. Planta Med. 76: 599-606.

PMID: # 19661619  Tchantchou, F. et al. 2009. J. Alzheimers Dis. 18: 787-798.

PMID: # 8026711  Vasseur, M. et al. 1994. Gen. Pharmacol. 25: 31-46.

Citations 1 to 3 of 3 total
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Rated 5 out of 5 by from Shi et al Shi et al. (PubMed ID 20333467) showed that bilobalide exhibited neuroprotective effects on human neuroblastoma cells and primary hippocampal neurons via the PI3K/Akt pathway. -SCBT Publication Review
Date published: 2015-01-24
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