Bicyclomycin benzoate A polar metabolite with activity against Gram negative bacteria

Bicyclomycin benzoate  (CAS 37134-40-0)

Bicyclomycin benzoate, CAS 37134-40-0 is rated 5.0 out of 5 by 1.
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Synonym: Bicyclomycin, 3'-benzoate
Application: A polar metabolite with activity against Gram negative bacteria
CAS Number: 37134-40-0
Purity: ≥99%
Molecular Weight: 406.39
Molecular Formula: C19H22N2O8
* Refer to Certificate of Analysis for lot specific data (including water content).
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Bicyclomycin is a polar metabolite first isolated from Streptomyces sapporonensis in 1972, with activity against Gram negative bacteria. The selective Gram negative profile of bicyclomycin is rare among Streptomyces metabolites. The benzoate contains a more exposed primary alcohol than its parent compound, bicyclomycin (sc-391755), making it more cell-permeable.

Physical State :
Solid
Solubility :
Soluble in ethanol, methanol, DMF, DMSO, and water (Partial).
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
DT7470000
PubChem CID :
71587135
SMILES :
C[C@](COC(=O)C1=CC=CC=C1)([C@@H](C23C(=O)N[C@](C(=C)CCO2)(C(=O)N3)O)O)O

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Bicyclomycin benzoate   Product Citations

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PMID: # 25661987  Pedrolli, D. et al. 2015. The FEBS journal. 282: 3230-42.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from D Heygere et al D Heygere et al. (PubMed ID 25999346) used bicyclomycin (BCM), a rho termination factor inhibitor that binds to a the ATPase subsite in rho, to study bacterial resistance in Mycobacterium tuberculosis. -SCBT Publication Review
Date published: 2015-03-26
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