BexaroteneA selective agonist of retinoid X receptors

Bexarotene (CAS 153559-49-0)

Bexarotene | CAS 153559-49-0 is rated 5.0 out of 5 by 1.
  • y_2019, m_8, d_23, h_3
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.13
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_217753, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 87ms
  • REVIEWS, PRODUCT
Synonym: 4-[1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethenyl)benzoic Acid; LG 100069; LG 1069; LG 69; LGD 1069; RO 26-4455; SR 11247; Targret; Targretin; Targretyn; Targrexin
Application: A selective agonist of retinoid X receptors
CAS Number: 153559-49-0
Purity: ≥98%
Molecular Weight: 348.48
Molecular Formula: C24H28O2
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Bexarotene is a selective RXR (retinoid X receptor) agonist used as an antineoplastic. Bexarotene is an activator of RXR α, RXR β and RXR γ.


References

Boehm, M.F., et al.: J. Med. Che., 37,2930 (1994), Gottardis, M.M., et al.: Cancer Res., 56, 5566 (1996), Mukherjee, R., et al.: Nature, 386, 407 (1997), Miller, V.A., et al.: J. Clin. Oncol., 15, 790 (1997)

Physical State :
Solid
Solubility :
Soluble in methanol, DMF (20 mg/ml), DMSO (50 mg/ml), water (<1 mg/ml at 25° C), and ethanol (25 mM).
Storage :
Store at -20° C
Melting Point :
230-231° C
Boiling Point :
489.67° C at 760 mmHg (Predicted)
Density :
1.04 g/cm3 (Predicted)
Refractive Index :
n20D 1.56 (Predicted)
IC50 :
RXR γ: EC5050 = 20 nM; RXR β: EC5050 = 25 nM; RXR α: EC5050 = 28 nM
Ki Data :
RXR β: Ki= 5.9 nM; RXR γ: Ki= 8.3 nM; RXR α: Ki= 14 nM
pK Values :
pKa: 4.08 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
DH6834830
PubChem CID :
82146
Merck Index :
14: 1194
MDL Number :
MFCD00932428
SMILES :
CC1=CC2=C(C=C1C(=C)C1=CC=C(C=C1)C(O)=O)C(C)(C)CCC2(C)C

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

What is the appearance of the compound?

Asked by: two2igm05
Thank you for your question. Bexarotene, sc-217753, is in white powder form.
Answered by: Chemical Support 4
Date published: 2017-04-17
  • y_2019, m_8, d_23, h_3CST
  • bvseo_bulk, prod_bvqa, vn_bulk_2.0.13
  • cp_1, bvpage1
  • co_hasquestionsanswers, tq_1
  • loc_en_US, sid_217753, prod, sort_[SortEntry(order=LAST_APPROVED_ANSWER_SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 131ms
  • QUESTIONS, PRODUCT
Rated 5 out of 5 by from Riancho Riancho, J. et al. (PubMed 26190974) found that Bexarotene, a selective retinoid X receptor (RXR) agonist, exhibited a neuroprotective effect in SOD1(G93A) mouse models of ALS. -SCBT Publication Review
Date published: 2015-03-19
  • y_2019, m_8, d_23, h_3
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.13
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_217753, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 83ms
  • REVIEWS, PRODUCT

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.