Betulin Betulin has been suggested to affect intracellular signaling in ethanol-induced liver cells via inhibiting ROS, TNFα and TNFβ.

Betulin  (CAS 473-98-3)

Betulin is rated 5.0 out of 5 by 1.
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Synonym: Lup-20(29)-ene-3β,28-diol
Application: A triterpene with a pentacyclic ring structure
CAS Number: 473-98-3
Purity: ≥95%
Molecular Weight: 442.72
Molecular Formula: C30H50O2
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ordering Information

PRODUCT NAME CATALOG # UNIT PRICE QTY FAVORITES
Betulin sc-234016 1 g $100.00

Betulin is a triterpene with a pentacyclic ring structure and hydroxyl groups in positions C3 and C28. Studies indicate that Betulin can effect intracellular signaling in ethanol-induced liver cells via inhibiting ROS, TNFα and TNFβ. In human cancer cells Betulin can induce mitochondrial cytochrome C release in human cancer cells, which results in apoptosis. Alternate studies on mice show that Betulin binds to melanocortin receptors and antagonizes the release of cAMP generation in mouse melanoma cells. Furthermore, Betulin has protective effects against cadmium induced apoptosis in human hepatoma cell lines. This occurs by inhibiting the activation of ROS, blocking Bid activation and suppressing the mitochondrial pathway.


References

1. Oh, S.H., et al. 2006. Toxicology. 220: 1-12. PMID: 16436312
2. Muceniece, R., et al. 2007. Cell Biochem. Funct. 25: 591-596. PMID: 17605140
3. Li, Y., et al. 2010. Mol. Carcinog. 49: 630-640. PMID: 20564340

Physical State :
Solid
Storage :
Store at 4° C
Melting Point :
256-257° C (lit.)
Boiling Point :
~522.3° C at 760 mmHg (Predicted)
Density :
~1.0 g/cm3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
72326
SMILES :
CC(=C)[C@@H]1CC[C@]2([C@H]1[C@H]3CC[C@@H]4[C@]5(CC[C@@H](C([C@@H]5CC[C@]4([C@@]3(CC2)C)C)(C)C)O)C)CO

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Guo Guo, MY. et al. (PubMed 26344430) reported that Betulin suppresses S. aureus-induced mammary gland inflammatory injury by regulating PPAR- in mice. -SCBT Publication Review
Date published: 2015-02-07
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