beta-Rubromycin A quinone antibiotic agent that inhibits reverse transcriptase

β-Rubromycin (CAS 27267-70-5)

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Application: A quinone antibiotic agent that inhibits reverse transcriptase
CAS Number: 27267-70-5
Molecular Weight: 536.45
Molecular Formula: C27H20O12
* Refer to Certificate of Analysis for lot specific data (including water content).
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β-Rubromycin is a quinone antibiotic agent. β-Rubromycin is found to inhibit reverse HIV-1 RT (transcrisptase from HIV-1) to a greater degree than it inhibits cellular DNA polymerase α. This compound also inhibits TERT (human telomerase), and is cytostatically active against different tumor cell lines.


References

Goldman ME, Salituro GS, Bowen JA et al. Mol Pharmacol. 38:20-25 (1990).

Physical State :
Solid
Solubility :
Soluble in chloroform.
Storage :
Store at -20° C
Boiling Point :
~874.8° C at 760 mmHg (Predicted)
Density :
~1.7 g/cm3 (Predicted)
Refractive Index :
n20D 1.72 (Predicted)
IC50 :
TERT: IC50 = 1.32 µM (human)
pK Values :
pKa: 7.23 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
5464074
MDL Number :
MFCD03095570
SMILES :
COC1=CC(=C(C2=C1C(=O)C3=C(C2=O)OC4(C3)CCC5=C(O4)C(=C6C(=C5)C=C(OC6=O)C(=O)OC)O)O)OC

Download SDS (MSDS)

Certificate of Analysis

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