beta-Catenin/Tcf Inhibitor, FH535 A cell-permeable compound that inhibits Wnt/β-catenin and PPAR

β-Catenin/Tcf Inhibitor, FH535 (CAS 108409-83-2)

β-Catenin/Tcf Inhibitor, FH535, CAS 108409-83-2 is rated 5.0 out of 5 by 1.
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Synonym: N-(2-Methyl-4-nitrophenyl)-2,5-dichlorobenzenesulfonamide
Application: A cell-permeable compound that inhibits Wnt/β-catenin and PPAR
CAS Number: 108409-83-2
Purity: ≥94%
Molecular Weight: 361.20
Molecular Formula: C13H10Cl2N2O4S
* Refer to Certificate of Analysis for lot specific data (including water content).
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β-Catenin/Tcf Inhibitor, FH535 is a sulfonamide-based and cell-permeable compound that exhibits a dual pathway inhibition against Wnt/β-catenin and PPAR. FH535 and its structurally similar analog, PPAR inhibitor GW9662, both exhibit inhibition of coactivator/PPAR binding, though only FH535 blocks β-catenin/PPAR interaction. Further, the antagonistic activity of FH535 does not involve the covalent modification of non-covalent interaction with the PPR ligand-binding site cysteine residue, which has been experimentally shown to be crucial for GW9662 action. β-Catenin/Tcf Inhibitor, FH535 is an inhibitor of GRIP1, PPAR-β, and PPAR-γ.


References

1. Handeli, Shlomo., et al., 2008. A small-molecule inhibitor of Tcf/beta-catenin signaling down-regulates PPARgamma and PPARdelta activities. Molecular cancer therapeutics. 7(3): 521-9. PMID: 18347139

Physical State :
Solid
Solubility :
Soluble in DMSO (100 mg/ml).
Storage :
Store at 4° C
Melting Point :
202.89° C (Predicted)
Boiling Point :
~526.3° C at 760 mmHg (Predicted)
Density :
~1.6 g/cm3 (Predicted)
Refractive Index :
n20D 1.65 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
3463933
MDL Number :
MFCD01212888
SMILES :
CC1=C(C=CC(=C1)[N+](=O)[O-])NS(=O)(=O)C2=C(C=CC(=C2)Cl)Cl

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Certificate of Analysis

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beta-Catenin/Tcf Inhibitor, FH535  Product Citations

See how others have used beta-Catenin/Tcf Inhibitor, FH535. Click on the entry to view the PubMed entry .

Citations 1 to 4 of 4 total

PMID: # 27718127  Hou, R. et al. 2016. Tumour Biol.

PMID: # 27481517  Yu, L. et al. 2016. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. 37: 13821-13829.

PMID: # 25765854  Vega, SL. et al. 2015. Integr Biol (Camb). 7: 435-46.

PMID: # 24781517  2014. Psychopharmacology (Berl.). 231: 4383-91.

Citations 1 to 4 of 4 total
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Rated 5 out of 5 by from Wu Wu, MY. et al. (PubMed 26185454) reported that the -Catenin/Tcf Inhibitor, FH535, inhibited metastasis and growth of pancreatic cancer cells. -SCBT Publication Review
Date published: 2015-04-18
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