Bax channel blocker A cell-permeable dibromocarbazolo-piperazinyl derivative that displays anti-apoptotic properties

Bax channel blocker

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Application: A cell-permeable dibromocarbazolo-piperazinyl derivative that displays anti-apoptotic properties
Purity: ≥95%
Molecular Weight: 695.3
Molecular Formula: C19H21Br2N3O 2CF3CO2H
* Refer to Certificate of Analysis for lot specific data (including water content).
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Bax Channel Blocker is a cell-permeable dibromocarbazolo-piperazinyl derivative that displays anti-apoptotic properties. Bax Channel Blocker effectively blocks Bid-induced cyctochrome c release from HeLa cell mitochondria by inhibiting Bax channel-forming activity.


References

Peixoto, P., et al. 2009. Biochem J. 423, 381. Bombrun, A., et al. 2003. J. Med. Chem. 46, 4365.

Physical State :
Solid
Solubility :
Soluble in DMSO.
Storage :
Store at 4° C
IC50 :
Bax-channel forming activity: IC50 = 520 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
16760310
SMILES :
C1CN(CCN1)CC(CN2C3=C(C=C(C=C3)Br)C4=C2C=CC(=C4)Br)O.C(=O)(C(F)(F)F)O.C(=O)(C(F)(F)F)O

Download SDS (MSDS)

Certificate of Analysis

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