Bax channel blocker A potent inhibitor of Bax-mediated mitochondrial cytochrome c release

Bax channel blocker (CAS 335165-68-9)

Bax channel blocker | CAS 335165-68-9 is rated 5.0 out of 5 by 1.
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Synonym: 3,6-Dibromo-α-(1-piperazinylmethyl)-9H-carbazole-9-ethanol dihydrochloride
Application: A potent inhibitor of Bax-mediated mitochondrial cytochrome c release
CAS Number: 335165-68-9
Purity: ≥98%
Molecular Weight: 540.12
Molecular Formula: C19H21Br2N3O•2HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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Bax channel blocker is a potent inhibitor of Bax-mediated mitochondrial cytochrome C release (IC50 = 0.52 μM). Suggested to inhibit Bax channel formation/activity.


References

1. Bombrun, A., et al. 2003. J. Med. Chem. 46: 4365-4368. PMID: 14521400

Physical State :
Solid
Solubility :
Soluble in water (5 mM), and DMSO (100 mM).
Storage :
Desiccate at room temperature
Refractive Index :
n20D ~1.71 (Predicted)
IC50 :
Bax-mediated mitochondrial cytochrome c release : IC50 = 0.52 µM
pK Values :
pKb: 9.14 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
2729026
MDL Number :
MFCD00276492
SMILES :
C1CN(CCN1)CC(CN2C3=C(C=C(C=C3)Br)C4=C2C=CC(=C4)Br)O.Cl.Cl

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Certificate of Analysis

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Bax channel blocker  Product Citations

See how others have used Bax channel blocker. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 19691447  Peixoto, PM. et al. 2009. Biochem. J. 423: 381-387.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Peixoto Peixoto, PM. et al. (PubMed 19691447) tested the efficacy of Bax channel blocker to inhibit bax-mediated release of mitochondrial cytochrome c. Found that Bax channel blocker significantly reduced apoptosis in FL5.12 cells compared to the control cells. -SCBT Publication Review
Date published: 2015-04-24
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