Barium chloride dihydrate

Barium chloride dihydrate (CAS 10326-27-9)

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Application: A soluble salt of barium and source of toxic Ba2+ ions
CAS Number: 10326-27-9
Purity: ≥99%
Molecular Weight: 244.26
Molecular Formula: BaCl22H2O
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Barium chloride dihydrate is a soluble inorganic salt of barium and a source of toxic and neuronally active Ba2+ ions. Barium chloride produces excitatory effects on neuronal signaling through mobilization of intracellular Ca2+. This has been correlated to causing increases in potential difference and short-circuit currents in stripped sheets of rat intestine with subsequent effects on intestinal secretion. The toxic effects of Ba2+ are mediated through neuronal excitation, and sub-toxic administration of Barium Chloride produces arrhythmias in animals. Barium Chloride-promoted arrhythmias have been employed in studies investigating antiarrhythmic compounds. Barium Chloride demonstrates selective inhibition of MMP-2 (matrix metalloproteinase 2), suggested to proceed through displacement by Ba2+ of a Ca2+ ion at the catalytic center of MMP-2.


References

1. Cathcart, E.P. and Clark, G.H. 1915. J. Physiol. 50: 119-127. PMID: 16993326
2. Rabkin, S.W., et al. 1982. Arch Int Pharmacodyn Ther. 257: 225-238. PMID: 6287953
3. Hardcastle, J., et al. 1983. J. Physiol. 344: 69-80. PMID: 6317855
4. Hardcastle, J., et al. 1985. J. Physiol. 361: 19-33. PMID: 3989726
5. Ziouti, N., et al. 2006. Anal. Biochem. 350: 159-161. PMID: 16430848

Appearance :
Crystalline
Physical State :
Solid
Solubility :
Soluble in water (very), and methanol. Insoluble in ethanol, acetone, and ethyl acetate.
pH :
5.2-8.2 (25° C, 5%)
Storage :
Store at room temperature
Density :
3.10 g/cm3 at 20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
CQ8751000
Transport :
UN 1564, Class 6.1, Packing group III
PubChem CID :
5284346
Merck Index :
14: 971
MDL Number :
MFCD00149154
EC Number :
233-788-1
SMILES :
O.O.[Cl-].[Cl-].[Ba+2]

Download SDS (MSDS)

Certificate of Analysis

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