BAPTA, Free Acid A selective calcium chelator with 105-fold greater affinity for Ca2+ than Mg2+

BAPTA, Free Acid (CAS 85233-19-8)

BAPTA, Free Acid | CAS 85233-19-8 is rated 5.0 out of 5 by 1.
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Synonym: 1,2-Bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid
Application: A selective calcium chelator with 105-fold greater affinity for Ca2+ than Mg2+
CAS Number: 85233-19-8
Purity: ≥ 97%
Molecular Weight: 476.44
Molecular Formula: C22H24N2O10
* Refer to Certificate of Analysis for lot specific data (including water content).
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BAPTA, Free Acid (1,2-bis-(o-Aminophenoxy)-ethane-N,N,N′,N′-tetraacetic acid) is a selective calcium chelator with 105-fold greater affinity for Ca2+ than for Mg2+. This product is a high quality and sensitive compound for calcium signaling studies, investigation of signal transduction and apoptotic cascades, and neuroscience research. BAPTA, Free acid is not cell permeable and is useful for manipulating extracellular Ca2+ levels. BAPTA is closely related to the well-known chelator EGTA [ethylene glycol bis(beta-aminoethyl ether)-N,N,N′,N′-tetraacetic acid] (sc-3593), but is less effected by pH changes and are more efficient at taking up and releasing Ca2+.
Additional BAPTA chelators available:
BAPTA tetrapotassium salt (sc-202076)
BAPTA/AM (sc-202488)
BAPTA-APM (sc-206966)
BAPTA-TMFM (sc-212043)
5,5i difluoro Bapta(AM) (sc-217247)
5,5i difluoro Bapta(K+ Salt) (sc-217248)
Bapta-FF (AM) (sc-217696)
BAPTA, Tetrasodium Salt (sc-278716)


References

1. Tsien, R.Y., et al. 1980. Biochemistry. 19: 2396-2404. PMID: 6770893
2. Kijima, H., et al. 1988. J. Physiol. 403: 135-149. PMID: 3150982
3. Tanabe, N., et al. 1988. Neurosci. Lett. 92: 52-57. PMID: 2847089
4. Tymianski, M., et al. 1994. J. Neurophysiol. 72: 1973-1992. PMID: 7823112
5. Li, L., et al. 1995. J. Cell. Physiol. 163: 105-114. PMID: 7896886
6. Hardie, R.C. 2005. Cell Calcium. 38: 547-556. PMID: 16140375

Physical State :
Solid
Solubility :
Soluble in water (partly miscible), DMSO (25 mg/ml), DMF (25 mg/ml), 0.3 N NaHCO3 (50 mg/ml), aqueous Acid, and aqueous Base.
Storage :
Store at -20° C
Melting Point :
174° C
Boiling Point :
766.57° C at 760 mmHg (Predicted)
Density :
1.49 g/cm3 (Predicted)
Refractive Index :
n20D 1.66 (Predicted)
pK Values :
pKa: 1.40 (Predicted), pKb: 5.96 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
MC0423000
PubChem CID :
104751
Merck Index :
14: 957
MDL Number :
MFCD00036255
Beilstein Registry :
5192406
SMILES :
C1=CC=C(C(=C1)N(CC(=O)O)CC(=O)O)OCCOC2=CC=CC=C2N(CC(=O)O)CC(=O)O

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Certificate of Analysis

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BAPTA, Free Acid  Product Citations

See how others have used BAPTA, Free Acid. Click on the entry to view the PubMed entry .

Citations 1 to 3 of 3 total

PMID: # 28497254  Angstadt, JD. et al. 2017. J. Comp. Physiol. A Neuroethol. Sens. Neural. Behav. Physiol. 203: 613-633.

PMID: # 27865353  Mohan, S. et al. 2016. Nutrition research (New York, N.Y.). 36: 1114-1120.

PMID: # 26673139  Galindo-Villegas, J. et al. 2016. J. Immunol. 196: 738-49.

Citations 1 to 3 of 3 total
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Rated 5 out of 5 by from Various publications cite the use of the Various publications cite the use of the highly sensitive and selective calcium chelator BAPTA, Free acid in calcium signaling studies, investigation of signal transduction and apoptotic cascades, and neuroscience research. BAPTA, Free acid is not cell permeable and is useful for manipulating extracellular Ca2+ levels. -SCBT Publication Review
Date published: 2015-03-28
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