Bafilomycin B1 An inhibitor of vacuolar-ATPase enzymes in fungi

Bafilomycin B1 (CAS 88899-56-3)

Bafilomycin B1 | CAS 88899-56-3 is rated 5.0 out of 5 by 1.
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Synonym: Setamycin
Application: An inhibitor of vacuolar-ATPase enzymes in fungi
CAS Number: 88899-56-3
Purity: 95%
Molecular Weight: 815.99
Molecular Formula: C44H65NO13
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Bafilomycin B1, a plecomacrolide originally found to be produced by different Streptomyces species, has been shown to display activity against gram-positive bacteria and fungi. This compound is shown to be a potent and selective inhibitor of all V-ATPases. Studies have demonstrated that Bafilomycin B1 inhibits the osteoclastic proton pump in vitro. In addition, this compound has displayed a capacity to have concentration-dependent effects on neuronal cell viability. Bafilomycin B1 may also promote the accumulation of autophagic vacuoles and trigger Bax-dependent apoptosis.


References

1. Werner, G., et al. 1984. J. Antibiot. 37: 110-117. PMID: 6423597
2. Dröse, S., et al. 1997. J. Exp. Biol. 200: 1-8. PMID: 9023991
3. Farina, C. and Gagliardi, S. 2002. Curr. Pharm. Des. 8: 2033-2048. PMID: 12171517
4. Shacka, J.J., et al. 2006. Autophagy. 2: 228-230. PMID: 16874105

Physical State :
Solid
Derived From :
Streptomyces sp. MST-AS5343
Solubility :
Soluble in methanol (5 mg/ml ), DMSO (5 mg/ml ), and acetone. Insoluble in water.
Storage :
Store at -20° C
Boiling Point :
939.43° C at 760 mmHg (Predicted)
Density :
1.22 g/cm3 (Predicted)
Refractive Index :
n20D 1.56 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
NG8841000
PubChem CID :
6440917
MDL Number :
MFCD00214150
Beilstein Registry :
4640118
SMILES :
C[C@H]1C/C(=C\\C=C/[C@@H](C(OC(=O)/C(=C\\C(=C/[C@H]([C@H]1O)C)\\C)/OC)[C@@H](C)[C@H]([C@H](C)[C@]2(C[C@H]([C@@H]([C@H](O2)C(C)C)C)OC(=O)/C=C/C(=O)NC3=C(CCC3=O)O)O)O)OC)/C

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Bafilomycin B1  Product Citations

See how others have used Bafilomycin B1. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 26230309  Cioffi, AG. et al. 2015. J. Am. Chem. Soc. 137: 10096-9.

PMID: # 23663353  Hwang, JY. et al. 2013. AMB Express. 3: 24.

Citations 1 to 2 of 2 total

What is the shipping temperature of this product?

Asked by: hawkeye11
This chemical, Bafilomycin B1 (CAS 88899-56-3), ships ambient.
Answered by: Chemical Support 1
Date published: 2017-03-30
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Rated 5 out of 5 by from Omura Omura, S. et al. (PubMed 7309621) reported the first isolation of the antibiotic Bafilomycin B1, extracted from the mycelia of a rare actinomycete strain KM-6054. -SCBT Publication Review
Date published: 2015-07-10
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